Maleylacetate reductase
In enzymology, a maleylacetate reductase (EC 1.3.1.32) is an enzyme that catalyzes the chemical reaction
- 3-oxoadipate + NAD(P)+ 2-maleylacetate + NAD(P)H + H+
| maleylacetate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.32 | ||||||||
| CAS no. | 69669-65-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are 3-oxoadipate, NAD+, and NADP+, whereas its 4 products are 2-maleylacetate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxoadipate:NAD(P)+ oxidoreductase. This enzyme is also called maleolylacetate reductase. This enzyme participates in 3 metabolic pathways: gamma-hexachlorocyclohexane degradation, benzoate degradation via hydroxylation, and 1,4-dichlorobenzene degradation.
References
- Gaal AB, Neujahr HY (1980). "Maleylacetate reductase from Trichosporon cutaneum". Biochem. J. 185 (3): 783–6. PMC 1161460. PMID 7387635.
- Gaal AB, Neujahr HY (1981). "Induction of phenol-metabolizing enzymes in Trichosporon cutaneum". Arch. Microbiol. 130 (1): 54–58. doi:10.1007/BF00527072. PMID 7305599.
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