Manogepix

Manogepix (E1210) is an isoxazole-based broad-spectrum antifungal.[1] Manogepix targets GPI-protein biosynthesis.

Manogepix
Clinical data
Other namesE1210, APX001A
ATC code
  • None
Identifiers
  • 6-Oxa-1(3),7(2)-dipyridina-2(5,3)-[1,2]oxazola-4(1,4)-benzenaheptaphan-12-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC12H18N4O2
Molar mass250.302 g·mol−1
3D model (JSmol)
  • c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N
  • InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
  • Key:WSEKTEUGRLFBSE-UHFFFAOYSA-N

Manogepix is the active metabolite of the prodrug fosmanogepix.[2]

References
  1. Pfaller MA, Hata K, Jones RN, Messer SA, Moet GJ, Castanheira M (October 2011). "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease. 71 (2): 167–170. doi:10.1016/j.diagmicrobio.2011.05.001. PMID 21696907.
  2. Badali H, Patterson HP, Sanders CJ, Mermella B, Gibas CF, Ibrahim AS, et al. (May 2021). "Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes". Antimicrobial Agents and Chemotherapy. 65 (6). doi:10.1128/AAC.02343-20. PMC 8315997. PMID 33722886.
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