Marisela Morales (neuroscientist)

Morales investigates the molecules, cells and neuronal pathways central to the neurobiology of drug addiction. She applies anatomical, cell molecular, cell biological and electrophysiological experimental approaches. Her laboratory's research focus on two issues: what is the brain circuitry through which addictive drugs have their habit-forming actions, and what are the neuroadaptations in this circuitry that accompany the transition from recreational to compulsive drug-taking?[1]

Morales investigates the neuronal properties and synaptic connectivity of the ventral tegmental area (VTA) to gain a better understanding of the interactions of the VTA with other brain structures in the processing and integration of information underlying behaviors associated with the neurobiology of drugs of addiction. Her laboratory has shown that glutamatergic neurons are also present in the VTA. Morales explores the neuronal connectivity of VTA glutamatergic neurons and their participation in animal behavior.[1] Her laboratory has found evidence indicating synaptic connectivity between the reward and the stress systems at the level of the VTA.[1]