Mary Bouxsein

Mary Larsen Bouxsein is an American biomechanical engineer and an orthopedic researcher. She is the president of the American Society for Bone and Mineral Research, director of the Centre of Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center, professor at the department of Orthopedic Surgery at Harvard Medical School. She is known for her work on bone density and the use of imaging to define the factors leading to bone fractures.

Mary Bouxsein
Alma materStanford University
Scientific career
ThesisPhysical activity and bone density (1992)

Education and career

Bouxsein graduated from Princeton High School (New Jersey) in 1982.[1] She completed her Bachelor of Science in general engineering and Bachelor of Arts in economics from the University of Illinois, Urbana-Champaign in 1987. She completed her Master of Science and Ph.D. in mechanical engineering from Stanford University.[2]

She joined Beth Israel Deaconess Medical Center and Harvard Medical School for a postdoctoral fellowship (1992–95). In 2001, she was appointed as assistant professor in the department of orthopedic surgery at Harvard Medical School. In 2006 she held joint positions as an adjunct assistant professor at Boston University, and in 2008 she also joined as a faculty member in the Massachusetts Institute of Technology Bioastronautics Program. As of 2023 she is a professor of orthopedic surgery at Beth Israel Deaconess Medical Center and Harvard Medical School.[2]

Research

Bouxsein is known for her work on bone biomechanics with the goal of understanding skeletal fragility. Her early work defined methods to quantify bone density,[3] and used ultrasound to predict the risk of bone fractures.[4] She has used animal models to examine bone structure[5] and examined osteoporosis in people.[6] She has also conducted research on spaceflight induced bone loss,[7] and stress fractures in military trainees.[8]

Selected publications
  • Bouxsein, Mary L; Boyd, Stephen K; Christiansen, Blaine A; Guldberg, Robert E; Jepsen, Karl J; Müller, Ralph (2010-06-07). "Guidelines for assessment of bone microstructure in rodents using micro-computed tomography". Journal of Bone and Mineral Research. 25 (7): 1468–1486. doi:10.1002/jbmr.141.
  • Boutroy, Stephanie; Bouxsein, Mary L.; Munoz, Francoise; Delmas, Pierre D. (2005). "In Vivo Assessment of Trabecular Bone Microarchitecture by High-Resolution Peripheral Quantitative Computed Tomography". The Journal of Clinical Endocrinology & Metabolism. 90 (12): 6508–6515. doi:10.1210/jc.2005-1258. ISSN 0021-972X.
  • Rosen, Clifford J; Bouxsein, Mary L (2006). "Mechanisms of Disease: is osteoporosis the obesity of bone?". Nature Clinical Practice Rheumatology. 2 (1): 35–43. doi:10.1038/ncprheum0070. ISSN 1745-8382.

Honors and awards

In 2015 Bouxsein was inducted into the American Institute for Medical and Biological Engineering.[9]

References
  1. Rapp, Goldie (2018-09-11). "From PHS to a career at MIT and Harvard". Shaw Local. Retrieved 2023-06-01.
  2. "Bouxsein Lab | Lab Members".
  3. Carter, Dennis R.; Bouxsein, Mary L.; Marcus, Robert (2009-12-03). "New approaches for interpreting projected bone densitometry data". Journal of Bone and Mineral Research. 7 (2): 137–145. doi:10.1002/jbmr.5650070204.
  4. Bouxsein, M. L.; Radloff, S. E. (1997-05-01). "Quantitative Ultrasound of the Calcaneus Reflects the Mechanical Properties of Calcaneal Trabecular Bone". Journal of Bone and Mineral Research. 12 (5): 839–846. doi:10.1359/jbmr.1997.12.5.839.
  5. Bouxsein, Mary L; Boyd, Stephen K; Christiansen, Blaine A; Guldberg, Robert E; Jepsen, Karl J; Müller, Ralph (2010-06-07). "Guidelines for assessment of bone microstructure in rodents using micro-computed tomography". Journal of Bone and Mineral Research. 25 (7): 1468–1486. doi:10.1002/jbmr.141.
  6. Rosen, Clifford J; Bouxsein, Mary L (2006). "Mechanisms of Disease: is osteoporosis the obesity of bone?". Nature Clinical Practice Rheumatology. 2 (1): 35–43. doi:10.1038/ncprheum0070. ISSN 1745-8382.
  7. Burkhart, Katelyn; Allaire, Brett; Bouxsein, Mary L. (2019-06-15). "Negative Effects of Long-duration Spaceflight on Paraspinal Muscle Morphology". Spine. 44 (12): 879–886. doi:10.1097/BRS.0000000000002959. ISSN 0362-2436.
  8. Popp, Kristin L.; Ackerman, Kathryn E.; Rudolph, Sara E.; Johannesdottir, Fjola; Hughes, Julie M.; Tenforde, Adam S.; Bredella, Miriam A.; Xu, Chun; Unnikrishnan, Ginu; Reifman, Jaques; Bouxsein, Mary L. (2021). "Changes in Volumetric Bone Mineral Density Over 12 Months After a Tibial Bone Stress Injury Diagnosis: Implications for Return to Sports and Military Duty". The American Journal of Sports Medicine. 49 (1): 226–235. doi:10.1177/0363546520971782. ISSN 0363-5465.
  9. "Mary Bouxsein Mary Larsen Bouxsein, Ph.D. To be Inducted into Medical and Biological Engineering Elite - AIMBE". March 5, 2015. Retrieved 2023-06-01.
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