Matthew P. Scott

Matthew P. Scott is an American biologist who was the tenth president of the Carnegie Institution for Science.[3] While at Stanford University, Scott studied how embryonic and later development is governed by proteins that control gene activity and cell signaling processes.[4] [5] He co-[6] discovered homeobox genes in Drosophila melanogaster working with Amy J. Weiner at Indiana University.[7][8]

Matt Scott
Born
Matthew P. Scott
CitizenshipUnited States
Alma materMassachusetts Institute of Technology
Known forHomeobox
SpouseMargaret T. Fuller
AwardsMember of the National Academy of Sciences (1999)[1]
Scientific career
FieldsDevelopmental biology
InstitutionsStanford University
Carnegie Institution for Science
University of Colorado Boulder
Indiana University
Doctoral advisorMary Lou Pardue
Notable studentsSean B. Carroll
Chris Q. Doe
Eileen Furlong (postdoc)[2]
Websiteprofiles.stanford.edu/matthew-scott

Among his laboratory's discoveries, he is recognized for the cloning of the patched gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene for the nevoid basal cell carcinoma syndrome, or Gorlin syndrome.[9][10]

Education

Scott completed a B.S. in 1975 and Ph.D. in Biology in 1980, both at Massachusetts Institute of Technology.[11]

Career and research

Scott served on the faculty of the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado starting in 1983. He moved to Stanford University in 1990 to join the faculty of the Department of Developmental Biology and the Department of Genetics. From 2002-2007 he served as Chair of Bio-X, Stanford's interdisciplinary biosciences program.[12]

Awards and honors

Personal life

He is married to Stanford developmental geneticist Margaret T. Fuller.

References
  1. "Matthew P. Scott".
  2. Furlong, Eileen E.M.; Profitt, David; Scott, Matthew P. (2001). "Automated sorting of live transgenic embryos". Nature Biotechnology. 19 (2): 153–156. doi:10.1038/84422. ISSN 1087-0156. PMID 11175730. S2CID 14228050.
  3. "Matthew P. Scott's Profile | Stanford Profiles".
  4. "Scott lab homepage at Stanford University". Archived from the original on 2008-12-04. Retrieved 2009-04-10.
  5. "HHMI Scientist Bio: Matthew P. Scott, Ph.D." Retrieved 2009-04-10.
  6. Amy J Weiner PhD Thesis Indiana University 1983
  7. Scott, M. P. (1984). "Structural Relationships among Genes That Control Development: Sequence Homology between the Antennapedia, Ultrabithorax, and Fushi Tarazu Loci of Drosophila". Proceedings of the National Academy of Sciences. 81 (13): 4115–4119. Bibcode:1984PNAS...81.4115S. doi:10.1073/pnas.81.13.4115. PMC 345379. PMID 6330741.
  8. Laughon, A.; Scott, M. P. (1984). "Sequence of a Drosophila segmentation gene: Protein structure homology with DNA-binding proteins". Nature. 310 (5972): 25–31. Bibcode:1984Natur.310...25L. doi:10.1038/310025a0. PMID 6330566. S2CID 4346123.
  9. Hooper, J. E.; Scott, M. P. (1989). "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning". Cell. 59 (4): 751–765. doi:10.1016/0092-8674(89)90021-4. PMID 2582494. S2CID 16246437.
  10. Johnson, R. L.; Rothman, A. L.; Xie, J.; Goodrich, L. V.; Bare, J. W.; Bonifas, J. M.; Quinn, A. G.; Myers, R. M.; Cox, D. R.; Epstein, E. H. Jr.; Scott, M. P. (1996). "Human homolog of patched, a candidate gene for the basal cell nevus syndrome". Science. 272 (5268): 1668–1671. Bibcode:1996Sci...272.1668J. doi:10.1126/science.272.5268.1668. PMID 8658145. S2CID 9160210.
  11. "Matthew P. Scott's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2023-03-30.
  12. "Biography: Matthew Scott". Center for Genetic Medicine, Northwestern University. Archived from the original on 2010-06-20. Retrieved 2009-04-10.
  13. "Scholar Profile, Matthew P. Scott". Searle Scholars program. Retrieved 2009-04-10.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.