Hydrochlorothiazide/triamterene

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene.[1][2][3] It is used to treat high blood pressure and edema (swelling).[1][2][3] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide.[1][2] It is taken by mouth.[1][2][3]

Hydrochlorothiazide/triamterene
Combination of
HydrochlorothiazideThiazide diuretic
TriamterenePotassium-sparing diuretic
Clinical data
Trade namesDyazide, Maxzide, others
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[1][2] Other serious side effects may include high blood potassium.[1][2] Use in pregnancy and breastfeeding is not generally recommended.[1][2] Use in those with significant kidney problems is not recommended.[1][2] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[1][2]

The combination was approved for medical use in the United States in 1965.[4] In 2020, it was the 131st most commonly prescribed medication in the United States, with more than 4 million prescriptions.[5][6]

References
  1. "Dyazide- hydrochlorothiazide and triamterene capsule". DailyMed. 31 October 2017. Retrieved 20 August 2020.
  2. "Maxzide-25- maxzide tablet Maxzide tablet". DailyMed. 20 July 2018. Retrieved 20 August 2020.
  3. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
  4. "Dyazide: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 20 August 2020.
  5. "The Top 300 of 2019". ClinCalc. Retrieved 7 October 2022.
  6. "Hydrochlorothiazide; Triamterene - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
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