Colorado Mesa University

Houston Hall has the reputation of being the first building on campus. Built in 1940, it is named for the college's first president, Dr. Clifford G. Houston. Before its construction, the college had occupied an abandoned school building (the old Lowell School) in the city's downtown area. During the 2011 expansion and renovation project, delicate care was taken to match the new wing's ornamental brick facade with that of the original building.

Dominguez Hall

Dominguez Hall was built in 2011 and is home to the Davis School of Business and the Center for Teacher Education. This building has several classrooms, including four large semi-circle lecture rooms, computer labs, small study rooms, study open spaces (indoors and outdoors), faculty offices, a coffee shop, and a boardroom.

Originally built in 1967 to house the college library, previously located in Houston Hall, Lowell Heiny Hall now houses University Authorities offices, Registrar's Office, President's Office, HR, Marketing, and faculty offices.

University Center

The University Center was built in 2010 to replace the aging W.W. Campbell College Center. It houses the main campus dining facilities, including Dining Hall, Bookcliff Cafe, Starbucks Coffee, and a small convenience store. The center also houses the Associated Student Government, The Criterion campus newspaper, KMSA 91.3FM, Bookstore, Ballroom, student lounges, MAV Card Office, and the Student Life office, which contains some club offices.

Formerly known as Saunders Field House, The Maverick Center houses all athletic facilities in one building, except for football and baseball. Facilities include Brownson Arena, El Pomar Natatorium, Hamilton Recreation Center, and Monfort Family Human Performance Lab. Adjacent to The Maverick Center are Walker Field soccer and lacrosse stadium, Elliot Tennis Complex, Bergman Softball Field, and the Maverick Pavilion.

The Moss Performing Arts Center, named for local Colorado Mesa University supporters John and Angie Moss, provides music, dance and theatre students with the facilities needed to let their creativity shine. The center, which recently underwent a $5.1 million renovation and expansion, is home to the 600-seat William S. Robinson Theatre, a 300-seat recital hall, the Walter Walker Reception Area, the Mesa Experimental Theatre, a design studio, numerous music practice rooms, smart technology classrooms, faculty offices and a dance studio.

Moss is the home to the Theatre and Music Departments which offer a variety of entertainment for the campus and local community throughout the year.

Tomlinson Library

By 1984 the library's collection had outgrown Lowell Heiny Library and plans were made to build the collection a new home. The new library was dedicated in 1986. Recognized as an architectural gem in American School and University magazine, the library was named for outgoing college president John U. Tomlinson in 1988 to honor his commitment to improved library services at the college. Tomlinson Library contains over 190,000 volumes, including a large government documents collection, and a geology library. It also houses the Ethridge Pottery Collection of prehistoric southwestern ceramics.

Known by the acronym "FIRS", this facility consisting of a laboratory building and a fenced-in body farm is located just outside Grand Junction.[6] As of January 2018, the decomposition of 11 bodies was under investigation with a focus on identification of microbial clocks, collections of microorganisms that appear and change in a predictable manner during the course of human body decomposition.[6]