Metallochaperones

Metallochaperones are a distinct class of molecular chaperones that facilitate intracellular transport of metal ions to metalloenzymes and metalloproteins in cells through protein-protein interactions.[1] The proteins ensure that the correct metal ion is acquired by its corresponding metalloenzyme. Metallochaperones are essential to the proper functioning of cells, playing a vital role in a large number of biological processes including respiration, photosynthesis, neurotransmission, and protein folding.[2]

Prior to the discovery of metallochaperones in the late 1990s, biologists believed that metal ions freely diffused within cells without the aid of auxiliary proteins. Today, it is well established that these molecules contribute to the intracellular homeostatic control of biometal ions.[3]

References
  1. Rosenzweig, Amy C (2002-06-01). "Metallochaperones: Bind and Deliver". Chemistry & Biology. 9 (6): 673–677. doi:10.1016/S1074-5521(02)00156-4. ISSN 1074-5521.
  2. Sekhon, Bhupinder Singh (2010-05-01). "Metallochaperones - an Overview". Current Chemical Biology. Retrieved 2019-01-21.
  3. Finney LA, O'Halloran TV (2003). "Transition metal speciation in the cell: insights from the chemistry of metal ion receptors". Science. 300 (5621): 931–6. Bibcode:2003Sci...300..931F. doi:10.1126/science.1085049. PMID 12738850. S2CID 14863354.


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