Methanogen homoaconitase
Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction
- (R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)
- (1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
- (1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
| Methanogen homoaconitase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.114 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
References
- Drevland RM, Jia Y, Palmer DR, Graham DE (October 2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". The Journal of Biological Chemistry. 283 (43): 28888–96. doi:10.1074/jbc.m802159200. PMC 2662002. PMID 18765671.
External links
- Methanogen+homoaconitase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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