Methionine-S-oxide reductase
Methionine-S-oxide reductase (EC 1.8.4.5, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase) is an enzyme with systematic name L-methionine:thioredoxin-disulfide S-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- L-methionine + thioredoxin disulfide + H2O L-methionine S-oxide + thioredoxin
| Methionine-S-oxide reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.8.4.5 | ||||||||
| CAS no. | 70248-65-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In the reverse reaction, dithiothreitol can replace reduced thioredoxin.
References
- Black, S.; Harte, E.M.; Hudson, B.; Wartofsky, L. (1960). "A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides". J. Biol. Chem. 235: 2910–2916.
- Ejiri SI, Weissbach H, Brot N (July 1979). "Reduction of methionine sulfoxide to methionine by Escherichia coli". Journal of Bacteriology. 139 (1): 161–4. PMC 216841. PMID 37234.
- Ejiri SI, Weissbach H, Brot N (March 1980). "The purification of methionine sulfoxide reductase from Escherichia coli". Analytical Biochemistry. 102 (2): 393–8. doi:10.1016/0003-2697(80)90173-6. PMID 6999943.
External links
- Methionine-S-oxide+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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