MicL sRNA

MicL sRNA
MicL sRNA
	Predicted secondary structure and sequence conservation of MicL small RNA
Identifiers
Rfam	RF02654
Other data
Domain(s)	Bacteria
GO	GO:0030371
SO	SO:0000370
PDB structures	PDBe

MicL RNA (mRNA-interfering complementary RNA regulator of Lpp) is a σ ^E transcription factor-dependent small non-coding RNA. It was discovered in E. coli. Together with MicA and RybB sRNAs, MicL sRNA down-regulates the synthesis of abundant outer membrane proteins in response to stress. MicL specifically targets mRNA of lipoprotein Lpp, preventing its translation.[1]

References

Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G (July 2014). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. doi:10.1101/gad.243485.114. PMC 4102768. PMID 25030700.

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[1] Guo MS, Updegrove TB, Gogol EB, Shabalina SA, Gross CA, Storz G (July 2014). "MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein". Genes & Development. 28 (14): 1620–1634. doi:10.1101/gad.243485.114. PMC 4102768. PMID 25030700.