Michael Elowitz

Michael B. Elowitz is a biologist and professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology,[1][2][3] and investigator at the Howard Hughes Medical Institute.[4] In 2007 he was the recipient of the Genius grant, better known as the MacArthur Fellows Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology.[5] He was the first to show how inherently random effects, or 'noise', in gene expression could be detected and quantified in living cells,[6] leading to a growing recognition of the many roles that noise plays in living cells. His work in Synthetic Biology and Noise represent two foundations of the field of Systems Biology. Since then, his laboratory has contributed to the development of synthetic biological circuits that perform a range of functions inside cells, and revealed biological circuit design principles underlying epigenetic memory, cell fate control, cell-cell communication, and multicellular behaviors.[7]

Michael Elowitz
NationalityAmerican
Alma materUniversity of California, Berkeley Princeton University
AwardsMacArthur Fellows Program
Scientific career
FieldsBiology
InstitutionsCalifornia Institute of Technology;
Howard Hughes Medical Institute
External video
video icon “Beat of life: Understanding the cell’s rhythms”, Michael Elowitz on cellular oscillations, Knowable Magazine

Career

His laboratory studies the dynamics of genetic circuits in individual living cells using synthetic biology, time-lapse microscopy, and mathematical modeling, with a particular focus on the way in which cells make use of noise to implement behaviors that would be difficult or impossible without it. Recently, his lab has expanded their approaches beyond bacteria to include eukaryotic and mammalian cells.[8]

Life

Elowitz grew up in Los Angeles, California, where he attended the humanities magnet at Alexander Hamilton High School (Los Angeles). He studied Physics and graduated with a B.A. from the University of California, Berkeley in 1992,[9] and from Princeton University with a Ph.D. in 1999.[10] In 1997–1998, he spent one year at the European Molecular Biology Laboratory at Heidelberg. Afterwards, he was a postdoctoral fellow at the Rockefeller University in New York City.

While working as a graduate student at Princeton he co-authored songs such as Sunday at the Lab[11] with Uri Alon.

Awards

Peer-reviewed publications

References

  1. "The Elowitz Lab [Caltech]". www.elowitz.caltech.edu.
  2. "Biology Division - Michael Elowitz". Archived from the original on 24 June 2010. Retrieved 27 March 2010.
  3. "Caltech Applied Physics - Not Found". www.aph.caltech.edu.
  4. "Michael B. Elowitz, PhD - HHMI.org".
  5. "Ten years of synergy". Nature. 463 (7279): 269–270. January 1, 2010. Bibcode:2010Natur.463R.269.. doi:10.1038/463269b. PMID 20090703.
  6. "Database of Cell Signaling and Virtual Journal - Science Signaling". stke.sciencemag.org.
  7. https://www.elowitz.caltech.edu/. {{cite web}}: Missing or empty |title= (help)
  8. "Gene Circuit Dynamics in Regulation and Differentiation", Howard Hughes Medical Institute
  9. Applied Physics at Caltech, retrieved March 9, 2010
  10. "Searle Scholars Program : 2007 News Archive". www.searlescholars.net.
  11. Sunday at the Lab performed by Uri Alon
  12. "2022 NAS Election". www.nasonline.org. Retrieved August 28, 2022.
  13. https://www.caltech.edu/about/news/three-caltech-elected-aaas-fellows-53054. {{cite web}}: Missing or empty |title= (help)
  14. "2011 HFSP Nakasone Award goes to Michael Elowitz - Human Frontier Science Program". www.hfsp.org.
  15. Presidential Early Career Award for Scientists and Engineers
  16. "20 Best Brains Under 40 - DiscoverMagazine.com".
  17. "Michael Elowitz - MacArthur Foundation". Archived from the original on March 15, 2012. Retrieved May 13, 2019.
  18. "Elowitz, Michael - The David and Lucile Packard Foundation".
  19. TR35 winners
  20. "Burroughs Wellcome Fund: Dr. Michael Elowitz". Archived from the original on 25 July 2011. Retrieved 27 March 2010.
  21. Li, Pulin; Markson, Joseph S.; Wang, Sheng; Chen, Siheng; Vachharajani, Vipul; Elowitz, Michael B. (April 5, 2018). "Morphogen gradient reconstitution reveals Hedgehog pathway design principles". Science. 360 (6388): 543–548. Bibcode:2018Sci...360..543L. doi:10.1126/science.aao0645. ISSN 0036-8075. PMC 6516753. PMID 29622726.
  22. Bintu, Lacramioara; Yong, John; Antebi, Yaron E.; McCue, Kayla; Kazuki, Yasuhiro; Uno, Narumi; Oshimura, Mitsuo; Elowitz, Michael B. (February 12, 2016). "Dynamics of epigenetic regulation at the single-cell level". Science. 351 (6274): 720–724. Bibcode:2016Sci...351..720B. doi:10.1126/science.aab2956. ISSN 0036-8075. PMC 5108652. PMID 26912859.
  23. Lin, Yihan; Sohn, Chang Ho; Dalal, Chiraj K.; Cai, Long; Elowitz, Michael B. (2015). "Combinatorial gene regulation by modulation of relative pulse timing". Nature. 527 (7576): 54–58. Bibcode:2015Natur.527...54L. doi:10.1038/nature15710. PMC 4870307. PMID 26466562.
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