Michal Hocek

Michal Hocek (born 11 December 1969 in Benešov, Czechoslovakia) is a Czech chemist. He is a group leader at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences and a professor of organic chemistry at Charles University in Prague. He specializes in the chemistry and chemical biology of nucleosides, nucleotides, and nucleic acids.

Michal Hocek
Born
Michal Hocek

(1969-12-11) December 11, 1969
Benešov, Czechoslovakia
NationalityCzech
Alma mater
Scientific career
Fields
Institutions
Doctoral advisorAntonín Holý
Websitehocekgroup.uochb.cas.cz

Career

Education and early career

Michal Hocek studied at the former Prague Institute of Chemical Technology (now University of Chemistry and Technology, Prague or UCT, Prague) under the supervision of Josef Kuthan. In 1993, he graduated with an MSc degree specializing in organic and medicinal chemistry. He enrolled in a PhD program at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) under the tutelage of Dr. Antonín Holý, completing his studies in 1996. In 1997, Hocek performed a one-year postdoctoral fellowship under the guidance of Léon Ghosez at the Université catholique de Louvain (Louvain-la-Neuve, Belgium). He returned to the IOCB and Holý's laboratory, where he worked as a staff scientist for five years from 1998 to 2002.[1]

In 2002, Hocek was promoted to group leader of the Group of Modified Nucleobases at the IOCB. From 2004 to 2006, he served as the head of the Department of Organic Synthesis for Biomedicinal Applications at the IOCB. In 2006, he completed a Doctor of Science degree (DSc) at the Academy of Sciences of the Czech Republic at UCT Prague. In the same year, he served as an associate professor at UCT Prague.[1][2]

2007 onward

In 2007, Hocek was promoted to the Head of Research Team at the IOCB, thus beginning his independent research career. From 2011 to 2014, he served as an associate professor in the Department of Organic and Nuclear Chemistry at Charles University in Prague. He became a full professor in 2014.[3][4]

Hocek has been an editor for several academic journals. From 1998 to 2011, he served as editor-in-chief of the Collection of the Czechoslovak Chemical Communications, and from 2011, he has served on the Editorial Advisory Board of the journals ChemPlusChem[5] and ChemBioChem.[6] In 2013, he was named an F1000 faculty member for chemical biology.[7] He is a currently a member of the Czech Chemical Society, the American Chemical Society, and the International Society for Nucleosides, Nucleotides, and Nucleic Acids.[1]

In September 2016, Hocek was featured[8] on Hyde Park Civilizace,[9] a Czech television show featuring prominent Czech and international scientists. As of February 2021, he has produced over 250 publications and numerous patents. His research articles have garnered over 7500 citations, and he has achieved an h-index of 45.

Research achievements

Hocek and his group have contributed significantly to organic chemistry and medicinal chemistry by developing methods to synthesize modified nucleobases, nucleosides, nucleotides, and nucleic acids through cross-coupling reactions[10] and C-H activation.[11] They discovered several novel classes of cytostatic agents with nanomolar antitumor activities based on substituted or fused deazapurine nucleosides.[12][13][14][15]

In the field of chemical biology, Hocek and his laboratories have developed a simple two-step synthesis of base-modified DNA through cross-coupling reactions of 2'-deoxyribonucleoside triphosphates (dNTPs) followed by polymerase incorporation.[16] They have discovered some modified dNTPs that are better substrates for polymerases than natural nucleotides.[17] The methodology is widely used for enzymatic synthesis of DNA or RNA-bearing fluorescent,[18] redox,[19] or reactive labels,[20] as well as for modulation of transcription.[21]

Awards and recognition
  • 1999: Alfred Bader Prize for Organic Chemistry from the Czech Chemical Society[2]
  • 2004: Otto Wichterle Premium for Younger Scientists
  • 2004: Prize of the Academy of Sciences for Younger Scientists
  • Since 2008: Chairman of the Symposium on the Chemistry of Nucleic Acid Components[22]
  • 2015: Praemium Academia from the Czech Academy of Sciences[23][24]
  • 2015: Fellow of ChemPubSoc Europe[25]
  • 2017: Elected member of the Learned Society of the Czech Republic[26]
  • 2019: Rudolf Lukes Prize of the Czech Chemical Society

References
  1. "Prof. Michal Hocek, PhD., DSc". Retrieved 6 December 2017.
  2. "Bader Award Holder". Retrieved 6 December 2017.
  3. "Prof. Ing. Michal Hocek, CSc., DSc". Retrieved 6 December 2017.
  4. "Prezident republiky jmenoval profesory". Retrieved 6 December 2017.
  5. "ChemPlusChem Editorial Board". ChemPlusChem. doi:10.1002/(ISSN)2192-6506.
  6. "ChemBioChem Editorial Advisory Board". ChemBioChem. doi:10.1002/(ISSN)1439-7633.
  7. "F1000 Prime". Retrieved 6 December 2017.
  8. "Michal Hocek (chemik, Ústav organické chemie a biochemie AV ČR)". Retrieved 6 December 2017.
  9. "Hyde Park Civilizace". Retrieved 6 December 2017.
  10. Čapek P, Pohl R, Hocek, M (2006). "Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines". Org. Biomol. Chem. 4 (11): 2278–2284. doi:10.1039/b604010a. PMID 16729137.
  11. Čerňa I, Pohl R, Klepetářová B, Hocek M (2008). "Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C-H Arylation Reactions". J. Org. Chem. 73 (22): 9048–9054. doi:10.1021/jo8018126. PMID 18937413.
  12. Bourderioux A, Nauš P, Perlíková P, Pohl R, Pichová I, Votruba I, Džubák P, Konečný P, Hajdúch M, Stray KM, Wang T, Ray AS, Feng JY, Birkus G, Cihlar T, Hocek M (2011). "Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C-H Arylation Reactions". J. Med. Chem. 54 (15): 5498–5507. doi:10.1021/jm2005173. PMID 21711054.
  13. Nauš P, Caletková O, Konečný P, Džubák P, Bogdanová K, Kolář M, Vrbková J, Slavětínská L, Tloušťová E, Perlíková P, Hajdúch M, Hocek M (2014). "Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides". J. Med. Chem. 57 (3): 1097–1110. doi:10.1021/jm4018948. PMID 24397620.
  14. Tichý M, Smoleń S, Tloušťová E, Pohl R, Oždian T, Hejtmánková K, Lišková B, Gurská S, Džubák P, Hajdúch M, Hocek M (2017). "Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides". J. Med. Chem. 60 (6): 2411–2424. doi:10.1021/acs.jmedchem.6b01766. PMID 28221790.
  15. Tokarenko A, Lišková B, Smoleń S, Táborská N, Tichý M, Gurská S, Perlíková P, Frydrych I, Tloušťová E, Znojek P, Mertlíková-Keiserová H, Poštová Slavětínská L, Pohl R, Klepetářová B, Khalid N, Wenren Y, Laposa RR, Džubák P, Hajdúch M, Hocek M (2018). "Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides". J. Med. Chem. 61 (20): 9347–9359. doi:10.1021/acs.jmedchem.8b01258. PMID 30281308.
  16. Hocek M (2014). "Synthesis of Base-Modified 2'-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology". J. Org. Chem. 79 (21): 9914–9921. doi:10.1021/jo5020799. PMID 25321948.
  17. Kielkowski P, Fanfrlík J, Hocek M (2014). "7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations". Angew. Chem. Int. Ed. 53 (29): 7552–7555. doi:10.1002/anie.201404742. PMID 24890276. S2CID 29238354.
  18. Dziuba D, Jurkiewicz P, Cebecauer M, Hof M, Hocek M (2016). "A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy". Angew. Chem. Int. Ed. 55 (1): 174–178. doi:10.1002/anie.201507922. PMID 26768820. S2CID 29907799.
  19. Hocek M, Fojta M (2011). "Nucleobase modification as redox DNA labelling for electrochemical detection". Chem. Soc. Rev. 40 (12): 5802–5814. doi:10.1039/C1CS15049A. PMID 21625726.
  20. Dadová J, Orság P, Pohl R, Brázdová M, Fojta M, Hocek M (2013). "Vinylsulfonamide and Acrylamide Modification of DNA for Crosslinking with Proteins". Angew. Chem. Int. Ed. 52 (40): 10515–10518. doi:10.1002/anie.201303577. PMID 23939933.
  21. Raindlová V, Janoušková M, Slavíčková M, Perlíková P, Boháčová S, Milisavljevič N, Šanderová H, Benda M, Barvík I, Krásný L, Hocek M (2016). "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases". Nucleic Acids Res. 44 (7): 3000–3012. doi:10.1093/nar/gkw171. PMC 4838386. PMID 27001521.
  22. "SCNAC 2017". Archived from the original on 8 December 2017. Retrieved 6 December 2017.
  23. "Academic Award – Praemium Academiae". Retrieved 6 December 2017.
  24. "Praemium Academiae for Michal Hocek". Angew. Chem. Int. Ed. 54 (37): 10711. 2015. doi:10.1002/anie.201506288.
  25. "ChemPubSoc Europe Fellows Program". Retrieved 6 December 2017.
  26. "Učená Společnost České republiky". Retrieved 6 December 2017.
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