MicroRNA 5008

MicroRNA 5008 is a protein that in humans is encoded by the MIR5008 gene.[3]

MIR5008
Identifiers
AliasesMIR5008, microRNA 5008
External IDsGeneCards: MIR5008
Orthologs
SpeciesHumanMouse
Entrez

100847072

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Ensembl

ENSG00000264483

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UniProt

n
a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)Chr 1: 227.94 – 227.94 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. MiRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

References
  1. GRCh38: Ensembl release 89: ENSG00000264483 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: MicroRNA 5008". Retrieved 2016-02-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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