MicroRNA let-7a-2

MIRLET7A2
Identifiers
Aliases	MIRLET7A2, LET7A2, MIRNLET7A2, let-7a-2, microRNA let-7a-2
External IDs	OMIM: 612142 GeneCards: MIRLET7A2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	122,146,593 bp[1]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; kidney; ; endometrium; ; blood; ; stomach; ; liver; ; left uterine tube; ; body of stomach; ; monocyte; ; intestine;
	n/a
	More reference expression data
	n/a
Orthologs
	406882
	n/a
	ENSG00000198975
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

MicroRNA let-7a-2 is a ncRNA that in humans is encoded by the MIRLET7A2 gene.[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

GRCh38: Ensembl release 89: ENSG00000198975 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: MicroRNA let-7a-2". Retrieved 2016-03-15.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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