MAP1B

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.[5][6]

MAP1B
Identifiers
AliasesMAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDsOMIM: 157129 MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B
Orthologs
SpeciesHumanMouse
Entrez

4131

17755

Ensembl

ENSG00000131711

ENSMUSG00000052727

UniProt

P46821

P14873

RefSeq (mRNA)

NM_005909
NM_032010
NM_001324255

NM_008634

RefSeq (protein)

NP_001311184
NP_005900

NP_032660

Location (UCSC)Chr 5: 72.11 – 72.21 MbChr 13: 99.56 – 99.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.[6]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[7] and RASSF1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000131711 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052727 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7873–6. Bibcode:1991PNAS...88.7873L. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920.
  6. "Entrez Gene: MAP1B microtubule-associated protein 1B".
  7. Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (Sep 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.
  8. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.