Miriam Cnop

Miriam Cnop (born 25 December 1970) is a Belgian researcher and physician specializing in diabetology. She is Professor of Medicine at Université Libre de Bruxelles and Clinical Director of Erasmus Hospital’s Endocrinology Department. Her work centered on type 2 diabetes, in particular mechanisms of lipotoxicity using human islets of Langerhans and human induced pluripotent stem cell-derived β Cells. She is an associate member of the Royal Academy of Medicine of Belgium. In 2013, her work was awarded the Oskar Minkowski prize from the European Association for the Study of Diabetes.

Miriam Cnop
Born (1970-12-25) 25 December 1970
Ixelles, Belgium
NationalityBelgian
EducationVrije Universiteit Brussel (MD/PhD)
OrganizationUniversité libre de Bruxelles
AwardsEFSD Rising Star
Oskar Minkowski Prize

Early life and education

Miriam Cnop was born in Ixelles in 1970. Her father is mathematician, Ivan Cnop, who was a professor at the Vrije Universiteit Brussel. She attended the Royal Athenaeum of Tervuren for her k-12 education.

In 1988, she started studying medicine at Vrije Universiteit Brussel. She graduated summa cum laude and valedictorian in 1995, realizing her graduate thesis on the effects of lipids on pancreatic beta cells under the supervision of Pipeleers.[1] She earned a PhD degree from the same institution in 2002.[2]

She was a post-doctoral fellow at University of Washington, Seattle, under the supervision of Steven Kahn, on a scholarship from the Belgian American Educational Foundation.[3] She is board certified in Internal Medicine and did her sub-specialization in Endocrinology at Université Libre de Bruxelles in 2003.[4]

Career and research

Cnop’s main research interest is pancreatic beta cell failure in type 2 diabetes and monogenic forms of diabetes. She contributed to show that lipotoxicity, the deleterious effect of saturated fatty acids, causes dysfunction and apoptosis[5] of the beta cell. Her team demonstrated that the pancreas reaches its total capital of beta cells at age 20 years after which beta cells age with the body and may succumb to metabolic stress .[6]

The monogenic forms of diabetes under study in her group include diseases due to mutations in genes with a role in endoplasmic reticulum stress, mitochondrial function and tRNA biology.[7] Her team described the impact of TRMT10A deficiency in mammals, highlighting its role in the pathogenesis of microcephaly and early onset diabetes. She was the first to show incretin deficiency in a specific type of diabetes caused by RFX6 gene mutations.[8] These monogenic forms may further our understanding of the complex processes leading to type 2 diabetes.[9]

She studied the association between Friedreich’s ataxia and diabetes in collaboration with other researchers from Université Libre de Bruxelles. While it was hitherto believed that this form of diabetes is due to insulin resistance, they showed that beta cell dysfunction and death are central to the pathogenesis of diabetes for patients presenting with this hereditary condition.[10]

Her lab is among the few to differentiate induced pluripotent stem cells from diabetic patients into pancreatic islet cells, in collaboration with Timo Otonkoski, Helsinki. This novel technology provides a unique opportunity to gain insight into the pathways leading to beta cell failure in diabetes and to test novel therapies.[11]

She participates in two European Union Innovative Medicines Initiatives, INNODIA[12] and Rhapsody,[13] on type 1 and type 2 diabetes. She also coordinates the European Union Horizon 2020 project T2DSystems that aims to develop a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes.[14]

Awards and recognitions

References
  1. "Miriam Cnop: Expertalia Profile".
  2. Cnop, Miriam (2002). Lipids, putative β cell pathogens in type 2 diabetes (PhD thesis). Vrije Universiteit Brussel.
  3. "BAEF Year 2000 Alumni".
  4. "Team Member: Miriam Cnop".
  5. Cnop, Miriam (2008). "Initiation and execution of lipotoxic ER stress in pancreatic beta cells". Journal of Cell Science. 121 (Pt 14): 2308–2318. doi:10.1242/jcs.026062. PMC 3675788. PMID 18559892.
  6. Cnop, Miriam (2010). "The long lifespan and low turnover of human islet beta cells estimated by mathematical modeling of lipofuscin accumulation". Diabetologia. 53 (2): 321–330. doi:10.1007/s00125-009-1562-x.
  7. Cnop, Miriam (2013). "tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans". PLOS Genetics. 9 (10): e1003888. doi:10.1371/journal.pgen.1003888. PMC 3814312.
  8. Cnop, Miriam (2017). "Heterozygous RFX6 protein truncating variants are associated with Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance". Nature Communications. 8 (1): 888. doi:10.1038/s41467-017-00895-9. PMC 5638866. PMID 29026101.
  9. "New type of diabetes caused by a genetic mutation". Science Daily/Université Libre de Bruxelles. 12 October 2017.
  10. Cnop, Miriam (2012). "Central role and mechanisms of Beta cell dysfunction and death in Friedreich ataxia-associated diabetes". Annals of Neurology. 72 (6): 971–982. doi:10.1002/ana.23698. PMC 4900175. PMID 23280845.
  11. "Prof Miriam Cnop: projects at Fondation ULB". fondation.ulb.ac.be.
  12. "Publications 2018". inonda.eu.
  13. "European Commission Grant n°115881".
  14. "Project 667191: Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes". cordis.europa.eu.
  15. "Morgagni Prize Laureates".
  16. "Diabète: prix Oskar Minkowski 2013 au Dr Miriam Cnop (Erasme, ULB)". VCP. 23 September 2013.
  17. "Minkowski Prize Laureates". EASD.org.
  18. "Lauréats: Prix Auguste Loubatières".
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