Mitochondrial ferritin

Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene.[5]

FTMT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFTMT, MTF, Mitochondrial ferritin, ferritin mitochondrial
External IDsOMIM: 608847 MGI: 1914884 HomoloGene: 110661 GeneCards: FTMT
Orthologs
SpeciesHumanMouse
Entrez

94033

67634

Ensembl

ENSG00000181867

ENSMUSG00000024510

UniProt

Q8N4E7

Q9D5H4

RefSeq (mRNA)

NM_177478

NM_026286

RefSeq (protein)

NP_803431

NP_080562

Location (UCSC)Chr 5: 121.85 – 121.85 MbChr 18: 52.46 – 52.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is classified as a metal-binding protein which is located within the mitochondria. After the protein is taken up by the mitochondria it can be processed into a mature protein and assemble functional ferritin shells.

Structure

Its structure was determined at 1.70 Å through the use of X-ray diffraction and contains 182 residues. It is 67% helical. The Ramachandran plot shows that the structure of mitochondrial ferritin is mainly alpha helical with a low prevalence of beta sheets.

References

  1. GRCh38: Ensembl release 89: ENSG00000181867 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024510 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Levi S, Corsi B, Bosisio M, Invernizzi R, Volz A, Sanford D, Arosio P, Drysdale J (July 2001). "A human mitochondrial ferritin encoded by an intronless gene". J. Biol. Chem. 276 (27): 24437–40. doi:10.1074/jbc.C100141200. PMID 11323407.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.