Morgagni Stewart Morel syndrome

Morgagni-Stewart-Morel syndrome is a condition with a wide range of associated endocrine problems including: diabetes mellitus, diabetes insipidus, and hyperparathyroidism.[2] Other signs and symptoms include headaches, vertigo, hirsutism, menstrual disorder, galactorrhoea, obesity, depression, and seizures.[2] It's characterized by a thickening of the inner table of the frontal part of the skull, a usually benign condition known as hyperostosis frontalis interna.[2][3] The syndrome was first described in 1765.[3] It is named after the Italian anatomist and pathologist Giovanni Battista Morgagni, the British neurologist Roy Mackenzie Stewart, and the Swiss psychiatrist Ferdinand Morel.

Morgagni Stewart Morel syndrome
Other namesHyperostosis frontalis interna,' Metabolic craniopathy
Morgagni Stewart Morel syndrome is inherited in an X-linked recessive manner(or autosomal dominant).[1]
SpecialtyEndocrinology

Cause

Diagnosis

The diagnosis of Morgagni-Stewart-Morel is based upon a radiological finding of hyperostosis frontalis interna. Diagnosis considers a combination of clinical features including obesity,[4] virilism, and mental disturbances.[5]

Treatment

Treatment is based upon the symptoms, and generally includes medication, diet and lifestyle modification for weight control. Seizures and headaches associated with hyperostosis frontalis interna (HFI) are treated with standard medications.[6]

References
  1. INSERM US14. "Morgagni Stewart Morel syndrome". Orphanet. Retrieved 1 November 2017.
  2. Nallegowda M, Singh U, Khanna M, Yadav SL, Choudhary AR, Thakar A (March 2005). "Morgagni Stewart Morel syndrome—additional features". Neurol India. 53 (1): 117–9. doi:10.4103/0028-3886.15078. hdl:1807/7758. PMID 15805672.
  3. She R, Szakacs J (2004). "Hyperostosis frontalis interna: case report and review of literature". Ann. Clin. Lab. Sci. 34 (2): 206–8. PMID 15228235.
  4. "Obesity: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2018-04-17.
  5. "Morgagni-Stewart-Morel syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17.
  6. "Morgagni-Stewart-Morel syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.