Morganellaceae

The Morganellaceae are a family of Gram-negative bacteria that include some important human pathogens formerly classified as Enterobacteriaceae. This family is a member of the order Enterobacterales in the class Gammaproteobacteria of the phylum Pseudomonadota. Genera in this family include the type genus Morganella, along with Arsenophonus, Cosenzaea, Moellerella, Photorhabdus, Proteus, Providencia and Xenorhabdus.[1]

Morganellaceae
Providencia alcalifaciens
Scientific classification
Domain:
Bacteria
Phylum:
Pseudomonadota
Class:
Gammaproteobacteria
Order:
Enterobacterales
Family:
Morganellaceae

Adeolu et al., 2016
Genera

The name Morganellaceae is derived from the Latin term Morganella, referring the type genus of the family and the suffix "-aceae", an ending used to denote a family. Together, Morganellaceae refers to a family whose nomenclatural type is the genus Morganella.[1]

Human pathogens

A number of Morganellaceae bacterial species are opportunistic human pathogens, including Proteus, Providencia, and occasionally Morganella in nosocomial settings.

Proteus

Three Proteus species P. vulgaris, P. mirabilis, and P. penneri are opportunistic human pathogens, most commonly resulting in urinary tract infections.[2] Proteus vulgaris is commonly found in the intestine in various animals, and is shed into manure and soil.

About 10–15% of kidney stones are struvite stones, caused by alkalinization of the urine by the action of the urease enzyme of Proteus (and other) bacterial species.[3]

Providencia

Providencia rettgeri is a common cause of traveller's diarrhea.[4]

Insect pathogens and symbionts

A number of Morganellaceae have intimate relationships with insects and other invertebrates.

Arsenophonus

Arsenophonus are endosymbiotic bacteria of various insects. In Nasonia parasitic wasps, Arsenophonus nasoniae acts as a reproductive manipulator by killing developing male wasps. This promotes an increased frequency of females in the population, which are the only biological sex that transmits Arsenophonus to the next generation. This type of interaction is referred to as "male-killing or son-killing."[5]

In flies and Lice, Arsenophonus-like bacteria act as primary symbionts faithfully transmitted from generation to generation.[5] In such relationships, the primary endosymbiont commonly supplements the host's metabolism by providing essential vitamins and nutrients that the host cannot synthesize itself.[6]

Photorhabdus and Xenorhabdus

Photorhabdus and Xenorhabdus are bacterial associates of entomopathogenic nematodes. These nematodes infect insects and regurgitate their Photorhabdus or Xenorhabdus bacteria into the insect blood (also called hemolymph). The bacteria then suppress the insect's immune response, increasing the success of the nematode parasite. As a result of this highly effective evolutionary strategy, entomopathogenic nematodes are commonly used as biological control agents against insect pests like corn rootworms.[7]

Providencia

Providencia are common bacterial species in the microbiome of Drosophila fruit flies.[8] In Drosophila melanogaster, Providencia rettgeri is a common pathogen isolated from wild-caught flies.[9] The fly immune system defends against this infection using a highly specific antimicrobial peptide that is required for defence against P. rettgeri, but not other Providencia species.[9][10]

Biochemical Characteristics and Molecular Signatures[1]

These bacteria are oxidase-negative, and negative for arginine decarboxylase and Voges–Proskauer test.

Seven conserved signature indels (CSIs) were identified for this family through genomic analyses in the proteins dihydrolipoamide succinyltransferase, Xaa-Pro dipeptidase, bifunctional UDP-sugar hydrolase (5'-nucleotidase), transcriptional repair coupling factor, phosphate acetyltransferase, histidine–tRNA ligase, and N-acetylmuramoyl-L-alanine amidase.[1] These molecular signatures provide a novel and reliable means of differentiating members of Morganellaceae from other families within the order Enterobacterales and all other bacteria.

Historical Systematics and Current Taxonomy

Morganellaceae, as of 2021, contains eight validly published genera.[11] Members of this family were originally members of the family Enterobacteriaceae, a large phylogenetically unrelated group of species with distinct biochemical characteristics and different ecological niches. The original assignment of species into the family Enterobacteriaceae was largely based on 16S rRNA genome sequence analyses, which is known to have low discriminatory power and the results of which changes depends on the algorithm and organism information used. Despite this, the analyses still exhibited polyphyletic branching, indicating the presence of distinct subgroups within the family.[12]

In 2016, Adeolu et al. proposed the division of Enterobacteriaceae into 7 novel families based on comparative genomic analyses and the branching pattern of various phylogenetic trees constructed from conserved genome sequences, 16S rRNA sequences and multilocus sequence analyses. Molecular markers, specifically conserved signature indels, specific to this family were also identified as evidence supporting the division independent of phylogenetic trees.[1]

References
  1. Adeolu, Mobolaji; Alnajar, Seema; Naushad, Sohail; S Gupta, Radhey (2016). "Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov". International Journal of Systematic and Evolutionary Microbiology. 66 (12): 5575–5599. doi:10.1099/ijsem.0.001485. ISSN 1466-5026. PMID 27620848.
  2. Guentzel MN (1996). Baron S; et al. (eds.). Escherichia, Klebsiella, Enterobacter, Serratia, Citrobacter, and Proteus. In: Barron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. ISBN 978-0-9631172-1-2. (via NCBI Bookshelf).
  3. Armbruster, Chelsea; Mobley, Harry; Pearson, Melanie (2018). "Pathogenesis of Proteus mirabilis Infection". EcoSal Plus. 8 (1). doi:10.1128/ecosalplus.ESP-0009-2017. PMC 5880328. PMID 29424333.
  4. Yoh, M; Matsuyama, J; Ohnishi, M; Takagi, K; Miyagi, H; Mori, K; Park, KS; Ono, T; Honda, T (2005). "Importance of Providencia species as a major cause of travellers' diarrhoea". J Med Microbiol. 54 (11): 1077–82. doi:10.1099/jmm.0.45846-0. PMID 16192440.
  5. Nováková, Eva; Hypša, Václav; Moran, Nancy A (2009). "Arsenophonus, an emerging clade of intracellular symbionts with a broad host distribution". BMC Microbiology. 9 (1): 143. doi:10.1186/1471-2180-9-143. PMC 2724383. PMID 19619300.
  6. Rockwell, Nathan C.; Lagarias, J. C.; Bhattacharya, Debashish (17 October 2014). "Primary endosymbiosis and the evolution of light and oxygen sensing in photosynthetic eukaryotes". Frontiers in Ecology and Evolution. 2 (66). doi:10.3389/fevo.2014.00066. PMC 4343542. PMID 25729749.
  7. Jaffuel, Geoffrey; Imperiali, Nicola; Shelby, Kent; Campos-Herrera, Raquel; Geisert, Ryan; Maurhofer, Monika; Loper, Joyce; Keel, Christoph; Turlings, Ted C. J.; Hibbard, Bruce E. (28 February 2019). "Protecting maize from rootworm damage with the combined application of arbuscular mycorrhizal fungi, Pseudomonas bacteria and entomopathogenic nematodes". Scientific Reports. 9 (1): 3127. Bibcode:2019NatSR...9.3127J. doi:10.1038/s41598-019-39753-7. PMC 6395644. PMID 30816250.
  8. Martinson, VG; Douglas, AE; Jaenike, J (2017). "Community structure of the gut microbiota in sympatric species of wild Drosophila". Ecology Letters. 20 (5): 629–639. doi:10.1111/ele.12761. PMID 28371064.
  9. Unckless RL, Howick VM, Lazzaro BP (January 2016). "Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila". Current Biology. 26 (2): 257–262. doi:10.1016/j.cub.2015.11.063. PMC 4729654. PMID 26776733.
  10. Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaitre B (February 2019). "Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach". eLife. 8. doi:10.7554/eLife.44341. PMC 6398976. PMID 30803481.
  11. "Family: Morganellaceae". lpsn.dsmz.de. Retrieved 2021-06-05.
  12. Francino, M. Pilar; Santos, Scott R.; Ochman, Howard (2006), "Phylogenetic Relationships of Bacteria with Special Reference to Endosymbionts and Enteric Species", The Prokaryotes, New York, NY: Springer New York, pp. 41–59, doi:10.1007/0-387-30746-x_2, ISBN 978-0-387-25496-8, retrieved 2021-06-02


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