Mutation frequency

Mutation frequency and mutation rates are highly correlated to each other. Mutation frequencies test are cost effective in laboratories [1] however; these two concepts provide vital information in reference to accounting for the emergence of mutations on any given germ line.[2][3]

There are several test utilized in measuring the chances of mutation frequency and rates occurring in a particular gene pool. Some of the test are as follows:

  • Avida Digital Evolution Platform [4]
  • Fluctuation Analysis [5]

Mutation frequency and rates provide vital information about how often a mutation may be expressed in a particular genetic group or sex.[6] Yoon et., 2009 suggested that as sperm donors ages increased the sperm mutation frequencies increased. This reveals the positive correlation in how males are most likely to contribute to genetic disorders that reside within X-linked recessive chromosome.[7] There are additional factors affecting mutation frequency and rates involving evolutionary influences. Since, organisms may pass mutations to their offspring incorporating and analyzing the mutation frequency and rates of a particular species may provide a means to adequately comprehend its longevity [5]

Aging

The time course of spontaneous mutation frequency from middle to late adulthood was measured in four different tissues of the mouse.[8] Mutation frequencies in the cerebellum (90% neurons) and male germ cells were lower than in liver and adipose tissue. Furthermore, the mutation frequencies increased with age in liver and adipose tissue, whereas in the cerebellum and male germ cells the mutation frequency remained constant[8]

Dietary restricted rodents live longer and are generally healthier than their ad libitum fed counterparts. No changes were observed in the spontaneous chromosomal mutation frequency of dietary restricted mice (aged 6 and 12 months) compared to ad libitum fed control mice.[9] Thus dietary restriction appears to have no appreciable effect on spontaneous mutation in chromosomal DNA, and the increased longevity of dietary restricted mice apparently is not attributable to reduced chromosomal mutation frequency.

References
  1. Araten, D., Golde, D., Zhang, R., Taler, H., Gargiulo, L., Notaro, G., & Luzzatto, L. (2005). A quantitative measurement for the human somatic mutation rate. Cancer Research, (65), 8111-8117.
  2. Peruzzi, B., Araten, D., Notaro, R., & Luzzatto, L. (2009). The use of pig-a as a sentinel gene for the study of the somatic mutation rate and the mutagenic agents in vivo. Mutation Research, (705), 3-10.
  3. Peruzzi, B., Araten, D., Notaro, R., & Luzzatto, L. (2009). The use of pig-a as a sentinel gene for the study of the somatic mutation rate and the mutagenic agents in vivo. Mutation Research, (705), 3-10.described mutation frequency as containing a segment of cells that includes a mutation within particular trait, and the authors defined mutation rates as being chances a innovative alteration will take place in hereditary trait due to cell division.
  4. Clune, J., Misevic, D., Ofria, C., Lenski, R., Elena, S. F., & Sanjuan, R. (2008). Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes. Computational Biology, 4(9), 1-8.
  5. Nishant, K., Singh, N., & Alani, E. (2009). Genomic mutation rates: what high-throughput methods can tell us. Bioessays, 31(9), 912-920.
  6. Yoon, S., Qin, J., Glaser, R., Jabs, E., Wexler, N., Sokol, R., Arnheim, N., & Calabrese, P. (2009). The ups and downs of mutation frequencies during aging can account for the apert syndrome paternal age effect. PLos Genetics, 5(7), 1-19.
  7. http://users.rcn.com./jkimball.ma.ultranet/BiologyPages/M/Mutations.html(http://users.rcn.com./jkimball.ma.ultranet/BiologyPages/M/Mutations.html)
  8. Hill KA, Halangoda A, Heinmoeller PW, Gonzalez K, Chitaphan C, Longmate J, Scaringe WA, Wang JC, Sommer SS. Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice. Environ Mol Mutagen. 2005 Jun;45(5):442-54. doi: 10.1002/em.20119. PMID 15690342
  9. Stuart GR, Oda Y, Boer JG, Glickman BW. No change in spontaneous mutation frequency or specificity in dietary restricted mice. Carcinogenesis. 2000 Feb;21(2):317-9. doi: 10.1093/carcin/21.2.317. PMID 10657975

See also
  • Allele frequency
  • Mutation
  • Mutation rate
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