MYO18A

MYO18A
Identifiers
Aliases	MYO18A, MYSPDZ, SPR210, myosin XVIIIA, MAJN, SP-R210
External IDs	OMIM: 610067 MGI: 2667185 HomoloGene: 7977 GeneCards: MYO18A
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	29,180,398 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	77,865,980 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; sural nerve; ; left ventricle; ; corpus callosum; ; right lobe of liver; ; skin of abdomen; ; bone marrow cells; ; putamen; ; nucleus accumbens;
	Top expressed in
	esophagus; ; lip; ; triceps brachii muscle; ; ankle; ; right ventricle; ; temporal muscle; ; skeletal muscle tissue; ; intestinal villus; ; internal carotid artery; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ADP binding; actin filament binding; ATPase activity; protein binding; ATP binding; RNA binding;
Cellular component	cytoplasm; membrane; trans-Golgi network; actomyosin; cytoskeleton; myosin complex; endoplasmic reticulum-Golgi intermediate compartment; Golgi membrane; Golgi apparatus; cell surface;
Biological process	Golgi organization; Golgi vesicle budding; actomyosin structure organization; DNA metabolic process; asymmetric Golgi ribbon formation; negative regulation of apoptotic process; positive regulation of protein secretion; cell migration; Golgi ribbon formation; regulation of macrophage activation; positive regulation of opsonization;
	Sources:Amigo / QuickGO
Orthologs
	399687
	360013
	ENSG00000196535
	ENSMUSG00000000631
	Q92614
	Q9JMH9
NM_001346765; NM_001346766; NM_001346767; NM_001346768; NM_078471;
	NM_203318
	NM_001291212; NM_001291213; NM_001291214; NM_001291215; NM_011586
NP_001333694; NP_001333695; NP_001333696; NP_001333697; NP_510880;
	NP_976063
	NP_001278141; NP_001278142; NP_001278143; NP_001278144; NP_035716
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000196535 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000631 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M (May 2003). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". J Biochem. 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.
"Entrez Gene: MYO18A myosin XVIIIA".

Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996). "Purification of a cell-surface receptor for surfactant protein A." J. Biol. Chem. 271 (27): 16375–83. doi:10.1074/jbc.271.27.16375. PMID 8663107.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Chang NS, Mattison J, Cao H, et al. (1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem. Biophys. Res. Commun. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site". Biochemistry. 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Yang CH, Szeliga J, Jordan J, et al. (2005). "Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A". J. Biol. Chem. 280 (41): 34447–57. doi:10.1074/jbc.M505229200. PMC 1762002. PMID 16087679.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196535 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000631 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12761286-5] Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M (May 2003). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". J Biochem. 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.

[entrez-6] "Entrez Gene: MYO18A myosin XVIIIA".

MYO18A

References

Further reading