N-substituted formamide deformylase

In enzymology, a N-substituted formamide deformylase (EC 3.5.1.91) is an enzyme that catalyzes the chemical reaction

N-benzylformamide + H2O formate + benzylamine
N-substituted formamide deformylase
Identifiers
EC no.3.5.1.91
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Thus, the two substrates of this enzyme are N-benzylformamide and H2O, whereas its two products are formate and benzylamine.[1]

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-benzylformamide amidohydrolase and is also called NfdA. The enzyme is produced by Arthrobacter pascens bacteria.[2]

References

  1. Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M (September 2004). "Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning". Proceedings of the National Academy of Sciences of the United States of America. 101 (38): 13726–31. Bibcode:2004PNAS..10113726F. doi:10.1073/pnas.0405082101. PMC 518824. PMID 15358859.
  2. Schomburg D, Schomburg I, Chang A, eds. (2009). "3.5.1.91 N-substituted formamide deformylase". Class 3 Hydrolases: EC 3.4.22-3.13. Springer Handbook of Enzymes (2nd ed.). Springer Science & Business Media. pp. 376–378. ISBN 9783540857051.


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