NACA (gene)

Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.[5][6][7]

NACA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNACA, NACA1, skNAC, HSD48, NAC-alpha, nascent polypeptide-associated complex alpha subunit, nascent polypeptide associated complex subunit alpha
External IDsOMIM: 601234 MGI: 106095 HomoloGene: 136025 GeneCards: NACA
Orthologs
SpeciesHumanMouse
Entrez

4666

17938

Ensembl

ENSG00000196531

ENSMUSG00000061315

UniProt

Q13765

P70670
Q60817

RefSeq (mRNA)

NM_001113199
NM_001282976
NM_013608

RefSeq (protein)

NP_001106670
NP_001269905
NP_038636
NP_001269905.1
NP_038636.2

Location (UCSC)Chr 12: 56.71 – 56.73 MbChr 10: 127.87 – 127.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.[6][8]

The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.[7]

Interactions

NACA has been shown to interact with BTF3, FADD,[9] C-jun,[10] and 3 members of taxilin family.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000196531 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061315 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide".
  6. Wiedmann B, Sakai H, Davis TA, Wiedmann M (August 1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. Bibcode:1994Natur.370..434W. doi:10.1038/370434a0. PMID 8047162. S2CID 4353902.
  7. Yotov WV, St-Arnaud R (February 1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome. 7 (2): 163–4. doi:10.1007/BF03035343. PMID 8835540. S2CID 33088429. Archived from the original on 2000-09-16.
  8. Rospert S, Dubaquié Y, Gautschi M (October 2002). "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. doi:10.1007/PL00012490. PMID 12475173. S2CID 8874233.
  9. Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039.
  10. Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (March 1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. doi:10.1128/MCB.18.3.1312. PMC 108844. PMID 9488446.
  11. Yoshida K, Nogami S, Satoh S, Tanaka-Nakadate S, Hiraishi H, Terano A, Shirataki H (May 2005). "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells. 10 (5): 465–76. doi:10.1111/j.1365-2443.2005.00848.x. PMID 15836775. S2CID 19426810.

Further reading


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