NAD(P)H dehydrogenase, quinone 2

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD. Then, in an oxidative phase, NQO2 binds to its quinone substrate and reduces the quinone to a dihydroquinone. Besides the two catalytic FAD, NQO2 also has two zinc ions. It is not clear whether the metal has a catalytic role. NQO2 is a paralog of NQO1.

NQO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNQO2, Nqo2, NMO2, Nmor2, Ox2, DHQV, DIA6, QR2, NAD(P)H quinone dehydrogenase 2, N-ribosyldihydronicotinamide:quinone reductase 2
External IDsOMIM: 160998 MGI: 104513 HomoloGene: 696 GeneCards: NQO2
Orthologs
SpeciesHumanMouse
Entrez

4835

18105

Ensembl

ENSG00000124588

ENSMUSG00000046949

UniProt

P16083

Q9JI75

RefSeq (mRNA)

NM_000904
NM_001290221
NM_001290222
NM_001318940

NM_001163239
NM_001163241
NM_001163242
NM_020282

RefSeq (protein)

NP_000895
NP_001277150
NP_001277151
NP_001305869

NP_001156711
NP_001156713
NP_001156714
NP_064678

Location (UCSC)Chr 6: 2.99 – 3.02 MbChr 13: 34.15 – 34.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NQO2 is a homodimer. NQO2 can be inhibited by resveratrol.[5] One of QR2's binding sites responds to 2-iodomelatonin, and has been referred to as MT3.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000124588 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046949 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NQO2 NAD(P)H dehydrogenase, quinone 2".
  6. Cardinali DP, Delagrange P, Dubocovich ML, Jockers R, Krause DN, Markus RP, Olcese J, Pintor J, Renault N, Sugden D, Tosini G, Zlotos DP (2019). "Melatonin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database". IUPHAR/BPS Guide to Pharmacology CITE. 2019 (4). doi:10.2218/gtopdb/F39/2019.4.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P16083 (Ribosyldihydronicotinamide dehydrogenase [quinone]) at the PDBe-KB.
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