NAP1L4

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.[5][6]

NAP1L4
Identifiers
AliasesNAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDsOMIM: 601651 MGI: 1316687 HomoloGene: 133933 GeneCards: NAP1L4
Orthologs
SpeciesHumanMouse
Entrez

4676

17955

Ensembl

ENSG00000205531
ENSG00000273562

ENSMUSG00000059119

UniProt

Q99733

Q78ZA7

RefSeq (mRNA)

NM_005969

NM_001285489
NM_001285490
NM_008672

RefSeq (protein)

NP_001272418
NP_001272419
NP_032698

Location (UCSC)Chr 11: 2.94 – 2.99 MbChr 7: 143.51 – 143.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.[6]

References

  1. ENSG00000273562 GRCh38: Ensembl release 89: ENSG00000205531, ENSG00000273562 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059119 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi:10.1093/hmg/5.11.1743. PMID 8923002.
  6. "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4".

Further reading


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