NASP (gene)

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene.[5][6] Multiple isoforms are encoded by transcript variants of this gene.

NASP
Identifiers
AliasesNASP, FLB7527, PRO1999, HMDRA1, nuclear autoantigenic sperm protein
External IDsOMIM: 603185 MGI: 1355328 HomoloGene: 133894 GeneCards: NASP
Orthologs
SpeciesHumanMouse
Entrez

4678

50927

Ensembl

ENSG00000132780

ENSMUSG00000028693

UniProt

P49321

Q99MD9

RefSeq (mRNA)

NM_001195193
NM_002482
NM_152298
NM_172164

NM_001081475
NM_001284229
NM_016777

RefSeq (protein)

NP_001182122
NP_002473
NP_689511

NP_001074944
NP_001271158
NP_058057

Location (UCSC)Chr 1: 45.58 – 45.62 MbChr 4: 116.46 – 116.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.[7] The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000132780 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028693 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE (Dec 1992). "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein". Dev Biol. 154 (1): 37–44. doi:10.1016/0012-1606(92)90045-I. PMID 1426632.
  6. "Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)".
  7. Alekseev OM, Widgren EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei". J. Biol. Chem. 280 (4): 2904–11. doi:10.1074/jbc.M410397200. PMID 15533935.

Further reading


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