NAV2

Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.[5][6][7] The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal development, including neurite outgrowth. NAV2 is an atRA-responsive gene.[7]

NAV2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNAV2, HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2, neuron navigator 2
External IDsOMIM: 607026 MGI: 2183691 HomoloGene: 52330 GeneCards: NAV2
Orthologs
SpeciesHumanMouse
Entrez

89797

78286

Ensembl

ENSG00000166833

ENSMUSG00000052512

UniProt

Q8IVL1

n/a

RefSeq (mRNA)

NM_001111018
NM_001111019
NM_001244963
NM_145117
NM_182964

NM_001111016
NM_175272

RefSeq (protein)

NP_001104488
NP_001104489
NP_001231892
NP_660093
NP_892009

n/a

Location (UCSC)Chr 11: 19.35 – 20.12 MbChr 7: 48.91 – 49.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The neuron navigator, Is also theorized to play a role in cellular growth and migration.[8] In addition, different isoform variants have been discovered for this gene. Connections have been drawn to Nav2 having an association with human neurocognitive disorders Alzheimer's disease and age-related phenotypes. It has been discussed that future studies of Nav2 could provide crucial information in understanding the pathophysiology of the disease and its related phenotypes.[9]

The NAV2 gene, which is extensively expressed in the brain and  is important to nervous system development, may play a role in Alzheimer's disease.[10] Alzheimer's disease is a chronic neurological illness whose prevalence rises rapidly as people reach the age of 65. According to reports, Alzheimer's disease is one of the top ten main causes of death in the United States.There are 50 introns and 38 exons in the neuron navigator 2 (NAV2) gene.[10] The NAV2 gene was shown to be strongly expressed in the brain, as well as the kidney, liver, thyroid, mammary gland, and spinal cord (and may be involved in cell proliferation, migration, and nervous system development).[10] NAV2 has recently been linked to episodic memory scores in Alzheimer's patients.To date, no study has looked into the link between the NAV2 gene and the risk or AAO of Alzheimer's disease.[10] NAV2 may be one of the processes linking blood pressure, cardiovascular disease, and neurodegenerative disorders, according to this study. NAV2 was found to be overexpressed in human colorectal cancer in another gene expression analysis, suggesting that it could be used as a predictive biomarker as well as a possible therapeutic target for colorectal cancer. However, the conducted study may have some limitations, so more research is needed to adequately understand the purpose of NAV2.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000166833 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052512 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.
  6. Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
  7. "Entrez Gene: NAV2 neuron navigator 2".
  8. "NAV2 neuron navigator 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
  9. Xu, Chun; Su, Brenda Bin; Lozano, Stephanie; Wang, Kesheng (2020-01-01), Martin, Colin R.; Preedy, Victor R. (eds.), "Chapter 1 - The neuron navigator 2 gene and Alzheimer's disease", Genetics, Neurology, Behavior, and Diet in Dementia, Academic Press, pp. 3–24, ISBN 978-0-12-815868-5, retrieved 2022-05-05
  10. Wang, Ke-Sheng; Liu, Ying; Xu, Chun; Liu, Xuefeng; Luo, Xingguang (2017-09-15). "Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease". Journal of Neuroimmunology. 310: 60–65. doi:10.1016/j.jneuroim.2017.06.010. ISSN 0165-5728. PMC 6167010. PMID 28778446.

Further reading


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