NBR1

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[5][6]

NBR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDsOMIM: 166945 MGI: 108498 HomoloGene: 7438 GeneCards: NBR1
Orthologs
SpeciesHumanMouse
Entrez

4077

17966

Ensembl

ENSG00000188554

ENSMUSG00000017119

UniProt

Q14596

P97432

RefSeq (mRNA)

NM_001291571
NM_001291572
NM_005899
NM_031858
NM_031862

NM_001252220
NM_001252222
NM_001252223
NM_008676

RefSeq (protein)

NP_001278500
NP_001278501
NP_005890
NP_114068

NP_001239149
NP_001239151
NP_001239152
NP_032702

Location (UCSC)Chr 17: 43.17 – 43.21 MbChr 11: 101.44 – 101.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[7]

Interactions

NBR1 has been shown to interact with FEZ1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000188554 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017119 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
  6. "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
  7. Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.
  8. Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading


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