NDC80

Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene.[5][6][7]

NDC80
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component, NDC80 kinetochore complex component
External IDsOMIM: 607272 MGI: 1914302 HomoloGene: 38141 GeneCards: NDC80
Orthologs
SpeciesHumanMouse
Entrez

10403

67052

Ensembl

ENSG00000080986

ENSMUSG00000024056

UniProt

O14777

Q9D0F1

RefSeq (mRNA)

NM_006101

NM_023294

RefSeq (protein)

NP_006092

NP_075783

Location (UCSC)Chr 18: 2.57 – 2.62 MbChr 17: 71.8 – 71.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25,[8] and SPC24. This protein complex has microtubule-binding domains.[9]

HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.[7]

Interactions

NDC80 has been shown to interact with MIS12,[10][11] NEK2[12][13] and PSMC2.[13]

References

  1. GRCh38: Ensembl release 89: ENSG00000080986 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024056 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen Y, Riley DJ, Chen PL, Lee WH (October 1997). "HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis". Molecular and Cellular Biology. 17 (10): 6049–56. doi:10.1128/mcb.17.10.6049. PMC 232454. PMID 9315664.
  6. Martin-Lluesma S, Stucke VM, Nigg EA (September 2002). "Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2". Science. 297 (5590): 2267–70. Bibcode:2002Sci...297.2267M. doi:10.1126/science.1075596. PMID 12351790. S2CID 7879023.
  7. "Entrez Gene: NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae)".
  8. Human kinetochore protein Spc25 Q9HBM1
  9. D'Archivio S, Wickstead B (February 2017). "Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes". The Journal of Cell Biology. 216 (2): 379–391. doi:10.1083/jcb.201608043. PMC 5294786. PMID 28034897.
  10. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  11. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
  12. Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (December 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation". The Journal of Biological Chemistry. 277 (51): 49408–16. doi:10.1074/jbc.M207069200. PMID 12386167.
  13. Chen Y, Sharp ZD, Lee WH (September 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". The Journal of Biological Chemistry. 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. PMID 9295362.

Further reading

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