NDFIP1
Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. [5]
Function
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].
References
- GRCh38: Ensembl release 89: ENSG00000131507 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000024425 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Nedd4 family interacting protein 1". Retrieved 2017-10-18.
Further reading
- Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS (2008). "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins". J. Biol. Chem. 283 (47): 32621–7. doi:10.1074/jbc.M804120200. PMID 18819914.
- Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
- Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. Bibcode:2009PNAS..10615489H. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
- Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. Bibcode:2010PNAS..10711429M. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
- Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
- Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
- Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLOS ONE. 9 (1): e87119. Bibcode:2014PLoSO...987119H. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
- Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
- Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.
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