NECAB2

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.[5][6]

NECAB2
Identifiers
AliasesNECAB2, EFCBP2, N-terminal EF-hand calcium binding protein 2, stip-2
External IDsOMIM: 618130 MGI: 2152211 HomoloGene: 62200 GeneCards: NECAB2
Orthologs
SpeciesHumanMouse
Entrez

54550

117148

Ensembl

ENSG00000103154

ENSMUSG00000031837

UniProt

Q7Z6G3

Q91ZP9

RefSeq (mRNA)

NM_019065
NM_001329748
NM_001329749

NM_054095

RefSeq (protein)

NP_001316677
NP_001316678
NP_061938

NP_473436

Location (UCSC)Chr 16: 83.97 – 84 MbChr 8: 120.17 – 120.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of NECAB2 function. A conditional knockout mouse line, called Necab2tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000103154 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031837 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience. 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. S2CID 18740496.
  6. "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2".
  7. "Salmonella infection data for Necab2". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Necab2". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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