NEGR1

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.[5]

NEGR1
Identifiers
AliasesNEGR1, DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1
External IDsOMIM: 613173 MGI: 2444846 HomoloGene: 41447 GeneCards: NEGR1
Orthologs
SpeciesHumanMouse
Entrez

257194

320840

Ensembl

ENSG00000172260

ENSMUSG00000040037

UniProt

Q7Z3B1

Q80Z24

RefSeq (mRNA)

NM_173808

NM_001039094
NM_177274

RefSeq (protein)

NP_776169

NP_001034183
NP_796248

Location (UCSC)Chr 1: 71.4 – 72.28 MbChr 3: 156.27 – 157.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

Variants of the NEGR1 gene may be associated with obesity and major depression.[6][7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000172260 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040037 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi:10.1074/jbc.274.12.8224. PMID 10075727.
  6. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. S2CID 764409.
  7. Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
  8. Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.