NEIL3

NEIL3
Identifiers
Aliases	NEIL3, FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3, nei like DNA glycosylase 3
External IDs	OMIM: 608934 MGI: 2384588 HomoloGene: 10094 GeneCards: NEIL3
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	177,362,936 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	54,092,100 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; stromal cell of endometrium; ; bone marrow; ; pancreatic ductal cell; ; bone marrow cells; ; rectum; ; thymus; ; appendix; ; lymph node;
	Top expressed in
	secondary oocyte; ; thymus; ; spermatid; ; spermatocyte; ; dermis; ; bone marrow; ; outer nuclear layer; ; hand; ; ganglionic eminence; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; zinc ion binding; hydrolase activity, hydrolyzing N-glycosyl compounds; metal ion binding; hydrolase activity, acting on glycosyl bonds; damaged DNA binding; catalytic activity; lyase activity; nucleic acid binding; hydrolase activity; DNA N-glycosylase activity; bubble DNA binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; single-stranded DNA binding; double-stranded DNA binding; class I DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cellular component	nucleoplasm; nucleus;
Biological process	nucleotide-excision repair; cellular response to DNA damage stimulus; metabolism; DNA repair; base-excision repair;
	Sources:Amigo / QuickGO
Orthologs
	55247
	234258
	ENSG00000109674
	ENSMUSG00000039396
	Q8TAT5
	Q8K203
	NM_018248
	NM_146208
	NP_060718
	NP_666320
	Wikidata
View/Edit Human	View/Edit Mouse

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.[5]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.[6]

References

GRCh38: Ensembl release 89: ENSG00000109674 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039396 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)".
Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109674 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039396 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)".

[pmid12509226-6] Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.