NEMF (gene)
Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.[5]
NEMF | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | NEMF, NY-CO-1, SDCCAG1, nuclear export mediator factor, IDDSAPN | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608378 MGI: 1918305 HomoloGene: 3458 GeneCards: NEMF | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a component of the ribosome quality control complex.[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.
References
- GRCh38: Ensembl release 89: ENSG00000165525 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000020982 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Nuclear export mediator factor".
- Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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