NEO1

Neogenin is a protein that in humans is encoded by the NEO1 gene.[5][6]

NEO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNEO1, IGDCC2, NGN, NTN1R2, neogenin 1
External IDsOMIM: 601907 MGI: 1097159 HomoloGene: 1870 GeneCards: NEO1
Orthologs
SpeciesHumanMouse
Entrez

4756

18007

Ensembl

ENSG00000067141

ENSMUSG00000032340

UniProt

Q92859

P97798

RefSeq (mRNA)

NM_001172623
NM_001172624
NM_002499

NM_001042752
NM_008684

RefSeq (protein)

NP_001166094
NP_001166095
NP_002490

n/a

Location (UCSC)Chr 15: 73.05 – 73.31 MbChr 9: 58.78 – 58.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

NEO1 has been shown to interact with PTK2.[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. [8]

References

  1. GRCh38: Ensembl release 89: ENSG00000067141 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032340 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
  6. "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
  7. Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
  8. Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology - Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

Further reading


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