NFAM1
NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene. [5]
Function
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].
References
- GRCh38: Ensembl release 89: ENSG00000235568 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000058099 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: NFAT activating protein with ITAM motif 1". Retrieved 2018-03-13.
Further reading
- Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi:10.1074/jbc.M211060200. PMID 12615919.
- Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation" (PDF). Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi:10.1152/ajpcell.00590.2005. PMID 17079331.
- Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi:10.1016/j.virol.2007.10.029. PMC 2289909. PMID 18031784.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.