NRN1
Neuritin 1 is a protein that in humans is encoded by the NRN1 gene. [5]
| NRN1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | NRN1, NRN, dJ380B8.2, neuritin 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607409 MGI: 1915654 HomoloGene: 9577 GeneCards: NRN1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
References
- GRCh38: Ensembl release 89: ENSG00000124785 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000039114 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Neuritin 1". Retrieved 2017-12-15.
Further reading
- Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Léger J, Corvol P, Germain S (2006). "Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer". FEBS Lett. 580 (14): 3395–400. doi:10.1016/j.febslet.2006.05.011. PMID 16723126. S2CID 10052776.
- Fujino T, Wu Z, Lin WC, Phillips MA, Nedivi E (2008). "cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival". J. Comp. Neurol. 507 (5): 1831–45. doi:10.1002/cne.21649. PMC 2828060. PMID 18265009.
- Chandler D, Dragović M, Cooper M, Badcock JC, Mullin BH, Faulkner D, Wilson SG, Hallmayer J, Howell S, Rock D, Palmer LJ, Kalaydjieva L, Jablensky A (2010). "Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 428–437. doi:10.1002/ajmg.b.30996. PMID 19569075. S2CID 24983584.
- Zhang L, Zhao Y, Wang CG, Fei Z, Wang Y, Li L, Li L, Zhen HN (2011). "Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma". Med. Oncol. 28 (3): 907–12. doi:10.1007/s12032-010-9537-9. PMID 20405246. S2CID 25680435.
- Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M (2011). "Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits". Proc. Natl. Acad. Sci. U.S.A. 108 (25): 10337–42. Bibcode:2011PNAS..10810337A. doi:10.1073/pnas.1104928108. PMC 3121858. PMID 21652774.
- Gao R, Wang L, Sun J, Nie K, Jian H, Gao L, Liao X, Zhang H, Huang J, Gan S (2014). "MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression". FEBS Lett. 588 (17): 3225–32. doi:10.1016/j.febslet.2014.07.004. PMID 25036738. S2CID 24215014.
- Choi Y, Lee K, Ryu J, Kim HG, Jeong AY, Woo RS, Lee JH, Hyun JW, Hahn S, Kim JH, Kim HS (2014). "Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease". PLOS ONE. 9 (8): e104121. Bibcode:2014PLoSO...9j4121C. doi:10.1371/journal.pone.0104121. PMC 4125179. PMID 25101829.
- Wang X, Liu C, Xu F, Cui L, Tan S, Chen R, Yang L, Huang J (2015). "Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells". Cell. Mol. Biol. Lett. 20 (3): 466–74. doi:10.1515/cmble-2015-0026. PMID 26208391.
- Fatjó-Vilas M, Prats C, Pomarol-Clotet E, Lázaro L, Moreno C, González-Ortega I, Lera-Miguel S, Miret S, Muñoz MJ, Ibáñez I, Campanera S, Giralt-López M, Cuesta MJ, Peralta V, Ortet G, Parellada M, González-Pinto A, McKenna PJ, Fañanás L (2016). "Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning" (PDF). World J. Biol. Psychiatry. 17 (2): 129–39. doi:10.3109/15622975.2015.1093658. hdl:2445/69596. PMID 26700405. S2CID 39722608.
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