NRXN2

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[5][6]

NRXN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNRXN2, neurexin 2
External IDsOMIM: 600566 MGI: 1096362 HomoloGene: 86984 GeneCards: NRXN2
Orthologs
SpeciesHumanMouse
Entrez

9379

18190

Ensembl

ENSG00000110076

ENSMUSG00000033768

UniProt

P58401
Q9P2S2

E9Q7X7

RefSeq (mRNA)

NM_001205234
NM_001205235
NM_020253
NM_001369363

RefSeq (protein)

NP_001192163
NP_001192164
NP_064649
NP_001356292

Location (UCSC)Chr 11: 64.61 – 64.72 MbChr 19: 6.47 – 6.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000110076 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033768 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–56. Bibcode:1992Sci...257...50U. doi:10.1126/science.1621094. PMID 1621094.
  6. "Entrez Gene: NRXN2 neurexin 2".

Further reading


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