NTN5

NTN5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4URT
Identifiers
Aliases	NTN5, netrin 5
External IDs	MGI: 2685330 HomoloGene: 17106 GeneCards: NTN5
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	48,673,081 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	45,343,980 bp[2]
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; cerebellar hemisphere; ; left uterine tube; ; canal of the cervix; ; skin of abdomen; ; putamen; ; nucleus accumbens; ; left lobe of thyroid gland;
	Top expressed in
	seminiferous tubule; ; superior frontal gyrus; ; cervix; ; hippocampus proper; ; stria vascularis; ; nerve; ; lip; ; spermatocyte; ; skeletal muscle tissue; ; left lung lobe;
	More reference expression data
	n/a
Orthologs
	126147
	243967
	ENSG00000142233
	ENSMUSG00000070564
	Q8WTR8
	Q3UQ22
	NM_145807
	NM_001033356; NM_001289692; NM_001289693; NM_001358870
	NP_665806
	NP_001028528; NP_001276621; NP_001276622; NP_001345799
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene.[5] Netrin-5 is included in the family of secreted laminin-related proteins.

Function

Netrin-5 functions are not fully clarified. However, it is believed to:

Plays an important role in neurogenesis by controlling the development of dendrites and acting as a guide for axons.[6][7]
Regulates cell migration in the brain during embryonic development.[8]
Prevents motor neuron cell body migration out of the neural tube.[8]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in HAVCR2 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how netrin-5 mutation contributes to disease.[9]

Considering the role of NTN5 in cell migration, it is very possible that netrin-5 has an important role in human carcinogenesis, although currently no tumor type with NTN5 alterations has been identified.[10]

References

GRCh38: Ensembl release 89: ENSG00000142233 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000070564 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.
Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, Sato K (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi:10.3389/fncel.2015.00146. PMC 4403520. PMID 25941474.
Ikegaya S, Iga Y, Mikawa S, Zhou L, Abe M, Sakimura K, et al. (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14: 570974. doi:10.3389/fnins.2020.570974. PMC 7726356. PMID 33324143.
Gaudet P, Livstone MS, Lewis SE, Thomas PD (September 2011). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. PMC 3178059. PMID 21873635.
Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMID 34493870. S2CID 237442349.
Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019: 3947123. doi:10.1155/2019/3947123. PMC 6408995. PMID 30923634.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142233 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070564 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "NTN5 netrin 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-11.

[6] Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, Sato K (2015). "Netrin-5 is highly expressed in neurogenic regions of the adult brain". Frontiers in Cellular Neuroscience. 9: 146. doi:10.3389/fncel.2015.00146. PMC 4403520. PMID 25941474.

[7] Ikegaya S, Iga Y, Mikawa S, Zhou L, Abe M, Sakimura K, et al. (2020). "Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice". Frontiers in Neuroscience. 14: 570974. doi:10.3389/fnins.2020.570974. PMC 7726356. PMID 33324143.

[:0-8] Gaudet P, Livstone MS, Lewis SE, Thomas PD (September 2011). "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium". Briefings in Bioinformatics. 12 (5): 449–462. doi:10.1093/bib/bbr042. PMC 3178059. PMID 21873635.

[9] Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMID 34493870. S2CID 237442349.

[10] Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of Nucleic Acids. 2019: 3947123. doi:10.1155/2019/3947123. PMC 6408995. PMID 30923634.