Nucleobindin 1

Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.[5][6]

NUCB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUCB1, CALNUC, NUC, nucleobindin 1
External IDsOMIM: 601323 MGI: 97388 HomoloGene: 4507 GeneCards: NUCB1
Orthologs
SpeciesHumanMouse
Entrez

4924

18220

Ensembl

ENSG00000104805

ENSMUSG00000030824

UniProt

Q02818

Q02819

RefSeq (mRNA)

NM_006184

NM_001163662
NM_008749

RefSeq (protein)

NP_006175

NP_001157134
NP_032775

Location (UCSC)Chr 19: 48.9 – 48.92 MbChr 7: 45.14 – 45.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

The human calnuc protein contains 461 amino acids and has a pI of 4.9.[7]

The protein contains the following regions and domains:

References

  1. GRCh38: Ensembl release 89: ENSG00000104805 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030824 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miura K, Hirai M, Kanai Y, Kurosawa Y (Feb 1997). "Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4". Genomics. 34 (2): 181–6. doi:10.1006/geno.1996.0263. PMID 8661046.
  6. "Entrez Gene: NUCB1 nucleobindin 1".
  7. Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG (June 1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein". J. Cell Biol. 141 (7): 1515–27. doi:10.1083/jcb.141.7.1515. PMC 2132997. PMID 9647645.
  8. Miura K, Titani K, Kurosawa Y, Kanai Y (August 1992). "Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure". Biochem. Biophys. Res. Commun. 187 (1): 375–80. doi:10.1016/S0006-291X(05)81503-7. PMID 1520323.
  9. Kanuru M, Raman R, Aradhyam GK (January 2013). "Serine protease activity of calnuc: regulation by Zn2+ and G proteins". J. Biol. Chem. 288 (3): 1762–73. doi:10.1074/jbc.M112.382846. PMC 3548486. PMID 23195954.

Further reading


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