NUDT11

NUDT11
Identifiers
Aliases	NUDT11, APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta, nudix hydrolase 11
External IDs	OMIM: 300528 MGI: 1930957 HomoloGene: 86995 GeneCards: NUDT11
EC number	3.6.1.60
Gene location (Human)
Chr.	X chromosome (human)[1]
End	51,496,592 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	5,967,164 bp[2]
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; Brodmann area 23; ; embryo; ; ganglionic eminence; ; middle temporal gyrus; ; superior frontal gyrus; ; oocyte; ; secondary oocyte; ; Brodmann area 46; ; nucleus accumbens;
	Top expressed in
	arcuate nucleus; ; dorsomedial hypothalamic nucleus; ; median eminence; ; ventromedial nucleus; ; suprachiasmatic nucleus; ; paraventricular nucleus of hypothalamus; ; barrel cortex; ; supraoptic nucleus; ; yolk sac; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate tetrakisphosphate diphosphatase activity; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; hydrolase activity; metal ion binding; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate pentakisphosphate diphosphatase activity; inositol bisdiphosphate tetrakisphosphate diphosphatase activity; endopolyphosphatase activity; diphosphoinositol-polyphosphate diphosphatase activity; bis(5'-adenosyl)-hexaphosphatase activity; bis(5'-adenosyl)-pentaphosphatase activity; m7G(5')pppN diphosphatase activity;
Cellular component	intracellular anatomical structure; nucleus; cytoplasm; cytosol;
Biological process	inositol phosphate metabolic process; diphosphoinositol polyphosphate metabolic process; diadenosine pentaphosphate catabolic process; diadenosine hexaphosphate catabolic process; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55190
	58242
	ENSG00000196368
	ENSMUSG00000073295
	Q96G61
	P0C027; P0C028
	NM_018159
	NM_021431
	NP_060629
	NP_001026834; NP_067406; NP_067406
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.[5][6]

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002).[supplied by OMIM][6]

References

GRCh38: Ensembl release 89: ENSG00000196368 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073295 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi:10.1074/jbc.M205476200. PMID 12105228.
"Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196368 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073295 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12105228-5] Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi:10.1074/jbc.M205476200. PMID 12105228.

[entrez-6] "Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

NUDT11

References

Further reading