NUDT15

Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene.[5]

NUDT15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT15, MTH2, NUDT15D, nudix hydrolase 15
External IDsOMIM: 615792 MGI: 2443366 HomoloGene: 10109 GeneCards: NUDT15
Orthologs
SpeciesHumanMouse
Entrez

55270

214254

Ensembl

ENSG00000136159

ENSMUSG00000033405

UniProt

Q9NV35

Q8BG93

RefSeq (mRNA)

NM_018283
NM_001304745

NM_172527
NM_001360484

RefSeq (protein)

NP_001291674
NP_060753

NP_766115
NP_001347413

Location (UCSC)Chr 13: 48.04 – 48.05 MbChr 14: 73.76 – 73.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

NUDT15 germline variants (e.g., a missense SNP:rs116855232, inducing R139C) have been linked to clinical usage of thiopurines (e.g., mercaptopurine) in acute lymphoblastic leukemia[6][7] as well as inflammatory bowel diseases to avoid thiopurine-induced leukopenia.[8][9] These variants also exhibit ethnicity-specific (e.g.,variant allele of rs116855232 is high is East Asians and Hispanics but low in Caucasians and Africans). Rare functional variants even singletons in this gene have also been identified to be related to thiopurine-induced myelotoxicity,[10] suggesting the whole gene screening should be taken to determine the initial dosage using of thiopurine.

References

  1. GRCh38: Ensembl release 89: ENSG00000136159 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033405 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Nudix hydrolase 15".
  6. Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, et al. (April 2016). "NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity". Nature Genetics. 48 (4): 367–73. doi:10.1038/ng.3508. PMC 5029084. PMID 26878724.
  7. Yang JJ, Landier W, Yang W, Liu C, Hageman L, Cheng C, et al. (April 2015). "Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia". Journal of Clinical Oncology. 33 (11): 1235–42. doi:10.1200/JCO.2014.59.4671. PMC 4375304. PMID 25624441.
  8. Yang SK, Hong M, Baek J, Choi H, Zhao W, Jung Y, et al. (September 2014). "A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia". Nature Genetics. 46 (9): 1017–20. doi:10.1038/ng.3060. PMC 4999337. PMID 25108385.
  9. Yin D, Xia X, Zhang J, Zhang S, Liao F, Zhang G, et al. (February 2017). "Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose". Oncotarget. 8 (8): 13575–13585. doi:10.18632/oncotarget.14594. PMC 5355121. PMID 28088792.
  10. Moriyama T, Yang YL, Nishii R, Ariffin H, Liu C, Lin TN, et al. (September 2017). "Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry". Blood. 130 (10): 1209–1212. doi:10.1182/blood-2017-05-782383. PMC 5606007. PMID 28659275.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9NV35 (Nucleotide triphosphate diphosphatase NUDT15) at the PDBe-KB.

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