NUDT6

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.[5][6][7]

NUDT6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6
External IDsOMIM: 606261 MGI: 2387618 HomoloGene: 31425 GeneCards: NUDT6
Orthologs
SpeciesHumanMouse
Entrez

11162

229228

Ensembl

ENSG00000170917

ENSMUSG00000050174

UniProt

P53370

Q8CH40

RefSeq (mRNA)

NM_198041
NM_007083

NM_001291044
NM_153561

RefSeq (protein)

NP_009014
NP_932158

NP_001277973
NP_705789

Location (UCSC)Chr 4: 122.89 – 122.92 MbChr 3: 37.46 – 37.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.

Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000170917 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000050174 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi:10.1210/mend.8.7.7984147. PMID 7984147.
  6. Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID 10022609. S2CID 28384265.
  7. "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.