Nucleoporin 153

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin.[5] On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

NUP153
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNUP153, HN153, nucleoporin 153kDa, nucleoporin 153
External IDsOMIM: 603948 MGI: 2385621 HomoloGene: 68442 GeneCards: NUP153
Orthologs
SpeciesHumanMouse
Entrez

9972

218210

Ensembl

ENSG00000124789

ENSMUSG00000021374

UniProt

P49790

n/a

RefSeq (mRNA)

NM_001278209
NM_001278210
NM_005124

NM_175749

RefSeq (protein)

NP_001265138
NP_001265139
NP_005115

n/a

Location (UCSC)Chr 6: 17.62 – 17.71 MbChr 13: 46.83 – 46.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Background

Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG.

Structure

Nucleoporin 153 has a mass of 153 kDA (hence its name). It is filamentous and it contains three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.[6]

Interactions

NUP153 has been shown to interact with SENP2[7][8] and KPNB1.[9][10][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000124789 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021374 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Moroianu J, Blobel G, Radu A (1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9699–704. Bibcode:1997PNAS...94.9699M. doi:10.1073/pnas.94.18.9699. PMC 23253. PMID 9275187.
  6. "Entrez Gene: NUP153 nucleoporin 153kDa".
  7. Hang, Jun; Dasso Mary (May 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. 277 (22): 19961–6. doi:10.1074/jbc.M201799200. ISSN 0021-9258. PMID 11896061.
  8. Zhang, Hong; Saitoh Hisato; Matunis Michael J (September 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. ISSN 0270-7306. PMC 135644. PMID 12192048.
  9. Nakielny, S; Shaikh S; Burke B; Dreyfuss G (April 1999). "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain". EMBO J. 18 (7): 1982–95. doi:10.1093/emboj/18.7.1982. ISSN 0261-4189. PMC 1171283. PMID 10202161.
  10. Kehlenbach, R H; Gerace L (June 2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro". J. Biol. Chem. 275 (23): 17848–56. doi:10.1074/jbc.M001455200. ISSN 0021-9258. PMID 10749866.
  11. Ben-Efraim, I; Gerace L (January 2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. ISSN 0021-9525. PMC 2199621. PMID 11266456.

Further reading

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