Nucleoporin 205

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.[5][6][7]

NUP205
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNUP205, C7orf14, NPHS13, nucleoporin 205kDa, nucleoporin 205
External IDsOMIM: 614352 MGI: 2141625 HomoloGene: 45971 GeneCards: NUP205
Orthologs
SpeciesHumanMouse
Entrez

23165

70699

Ensembl

ENSG00000155561

ENSMUSG00000038759

UniProt

Q92621

n/a

RefSeq (mRNA)

NM_015135
NM_001329434

NM_027513

RefSeq (protein)

NP_001316363
NP_055950

n/a

Location (UCSC)Chr 7: 135.56 – 135.65 MbChr 6: 35.15 – 35.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.[5] It has also been recently shown that Nup205 is required for proper viral gene expression.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000155561 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038759 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NUP205 nucleoporin 205kDa".
  6. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  7. Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
  8. Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG (Nov 2014). "Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression". J Virol. 88 (22): 13249–59. doi:10.1128/JVI.00933-14. PMC 4249058. PMID 25210169.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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