Nucleoporin 88

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.[5][6]

NUP88
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP88, nucleoporin 88, FADS4
External IDsOMIM: 602552 MGI: 104900 HomoloGene: 1901 GeneCards: NUP88
Orthologs
SpeciesHumanMouse
Entrez

4927

19069

Ensembl

ENSG00000108559

ENSMUSG00000040667

UniProt

Q99567

Q8CEC0

RefSeq (mRNA)

NM_002532
NM_001320653

NM_001083331
NM_001276406
NM_172394

RefSeq (protein)

NP_001307582
NP_002523

NP_001076800
NP_001263335
NP_765982

Location (UCSC)Chr 17: 5.36 – 5.42 MbChr 11: 70.83 – 70.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.[6]

Interactions

NUP88 has been shown to interact with NUP98.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000108559 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040667 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti KG, Fransen J, Grosveld G (Mar 1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMC 1169681. PMID 9049309.
  6. "Entrez Gene: NUP88 nucleoporin 88kDa".
  7. Griffis ER, Xu S, Powers MA (Feb 2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995. PMID 12589057.

Further reading


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