NUTF2

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.[4][5][6]

NUTF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUTF2, NTF2, PP15, NTF-2, nuclear transport factor 2
External IDsOMIM: 605813 MGI: 3704482 HomoloGene: 110745 GeneCards: NUTF2
Orthologs
SpeciesHumanMouse
Entrez

10204

621832

Ensembl

ENSG00000102898

n/a

UniProt

P61970

P61971

RefSeq (mRNA)

NM_005796
NM_001322038
NM_001322039
NM_001322040
NM_001322041

XM_001473957

RefSeq (protein)

NP_080808
NP_001344158
NP_001344159

Location (UCSC)Chr 16: 67.85 – 67.87 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[6]

Interactions

NUTF2 has been shown to interact with Nucleoporin 62[4][7] and RAN.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000102898 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol. 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498. PMID 7744965.
  5. Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res. 16 (10): 4721. doi:10.1093/nar/16.10.4721. PMC 336660. PMID 3380696.
  6. "Entrez Gene: NUTF2 nuclear transport factor 2".
  7. Hu T, Guan T, Gerace L (Aug 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
  8. Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS (Nov 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.
  9. Stewart M, Kent HM, McCoy AJ (Apr 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885.

Further reading


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