Nancy Allbritton

Nancy Allbritton is a Professor of Bioengineering and the Frank & Julie Jungers Dean of the College of Engineering at the University of Washington.[1] She was previously a Kenan Professor and Chair in the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University.[2]

Nancy Allbritton
NationalityAmerican
Alma materLouisiana State University (BS)
Johns Hopkins University (MD)
Massachusetts Institute of Technology (PhD)
Known forSingle-cell analysis
Scientific career
FieldsBiomedical Engineering
InstitutionsUniversity of Washington University of North Carolina at Chapel Hill and North Carolina State University

She is best known for her work in single-cell analysis. Using engineering methods, Allbritton creates tools for better understanding and manipulating living cells and tissues. Microengineered platforms, microfluidics, and novel biochemical assays enable scientists to study cell signaling and signal transduction at the single-cell level.[3]

Education

Allbritton received a bachelor of science with a major in physics from Louisiana State University, Baton Rouge in 1979. She received a doctor of medicine from Johns Hopkins University in 1985 and a doctor of philosophy in medical physics and medical engineering from the Massachusetts Institute of Technology in 1987.[4]

Career

Allbritton was a postdoctoral fellow at Stanford University from 1989 to 1994.[5] She then became a Professor at the University of California at Irvine, teaching in the departments of Physiology and Biophysics, Biomedical Engineering, Chemistry, Chemical Engineering and Materials Science. She remained at UC Irvine for 13 years, from 1994-2007.[5]

In 2007 Allbritton joined the University of North Carolina at Chapel Hill, becoming a Kenan Distinguished Professor. From 2009-2019 she was the Chair of the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University.[2] She has held faculty appointments in Chemistry, Pharmacology and Applied Physical Sciences at UNC, and in the Department of Materials Science and Engineering at NC State.[6]

As of November 1, 2019, Allbritton became a Professor of Bioengineering and the Frank & Julie Jungers Dean of Engineering at the University of Washington College of Engineering.[7][1]

Allbritton was appointed a co-editor of the Annual Review of Analytical Chemistry in 2021.[8]

Research interests

Allbritton's interest in single-cell analysis have hinged on the use of capillary electrophoresis (CE) and microfabricated technologies. Through this work she has studied lipid signaling at the single-cell level, the isolation cytotoxic t-cells with specific properties, and the capture of colonic crypts. In the organ-on-a-chip field,[9] Allbritton has used fabrication technologies from electronics and microfluidics to develop devices that effectively recreate the environment of both the small and large intestine.[10][11] These include micro total analysis systems[12][13] and microraft arrays.[14] In the area of dielectrophoresis (DEP), Allbritton's lab works on the transfer of DEP-based systems out of laboratories and into clinical use.[15]

Awards

Patents
  • "Fast controllable laser lysis of cells for analysis" Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg U.S. Patent No. US6156576A
  • "Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility" Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg U.S. Patent No. 6335201B1
  • "Method to measure the activation state of signaling pathways in cells" Nancy Allbritton, Christopher Sims U.S. Patent No. 7236888B2
  • "Chemical modifications to polymer surfaces and the application of polymer grafting to biomaterials" Nancy Allbritton, Christopher Sims, Guann-Pyng Li, Mark Bachman, Shuwen Hu, Xueqin Ren U.S. Patent No. 20050237480A1
  • "Systems and methods for efficient collection of single cells and colonies of cells and fast generation of stable transfectants" Nancy Allbritton, Christopher E. Sims, Yuli Wang, Mark Bachman, Guann-Pyng Li, Eric Stanbridge U.S. Patent No. 7759119B2
  • "Method and device for cell selection and collection in an isolated culturing environment" Nancy Allbritton, Christopher Sims, Wei Xu U.S. Patent No. 20110294208A1
  • "Array of micromolded structures for sorting adherent cells" Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah U.S. Patent No. 9068155B2

References
  1. Holtz August 13, 2019, Jackson (August 13, 2019). "Dr. Nancy Allbritton named dean of UW's College of Engineering". UW News. Retrieved 2020-06-24.
  2. "Meet the Team | Single-Cell Isolation and Recovery". Cellmicrosystems.com. Retrieved 2017-05-01.
  3. "Distinguished Seminar Series: Nancy Allbritton, Professor and Chair Department of Biomedical Engineering University of North Carolina & North Carolina State University". UCDavis Biomedical Engineering. October 30, 2014. Retrieved 2 August 2018.
  4. "Nancy Allbritton | UW Bioengineering". 2020-04-27. Retrieved 2022-10-06.
  5. "Nancy Allbritton". College of Engineering. University of Washington. Retrieved 8 September 2021.
  6. Lancaster, Brent (August 23, 2019). "Allbritton leaving Joint Department of Biomedical Engineering". College of Engineering News. NC State University. Retrieved 8 September 2021.
  7. "Nancy L. Allbritton". American Institute of Chemical Engineers. 26 May 2020. Retrieved 8 September 2021.
  8. "Annual Review of Analytical Chemistry, Current Editorial Committee". Annual Reviews. Retrieved 9 July 2021.
  9. Ma, Chao; Peng, Yansong; Li, Hongtong; Chen, Weiqiang (February 2021). "Organ-on-a-Chip: A New Paradigm for Drug Development". Trends in Pharmacological Sciences. 42 (2): 119–133. doi:10.1016/j.tips.2020.11.009. ISSN 0165-6147. PMC 7990030. PMID 33341248.
  10. Landhuis, Esther (26 September 2019). "Microbial chemistry gains fresh focus". Nature. 573 (7775): 615–616. Bibcode:2019Natur.573..615L. doi:10.1038/d41586-019-02853-5. PMID 31551561.
  11. "Researchers awarded $5.3 million to develop novel gut-on-a-chip technology". UNC College of Arts & Sciences. October 12, 2015. Retrieved 8 September 2021.
  12. Zhuang, Jianjian; Yin, Juxin; Lv, Shaowu; Wang, Ben; Mu, Ying (September 2020). "Advanced "lab-on-a-chip" to detect viruses – Current challenges and future perspectives". Biosensors and Bioelectronics. 163: 112291. doi:10.1016/j.bios.2020.112291. PMC 7215165. PMID 32421630.
  13. Kovarik, Michelle L.; Ornoff, Douglas M.; Melvin, Adam T.; Dobes, Nicholas C.; Wang, Yuli; Dickinson, Alexandra J.; Gach, Philip C.; Shah, Pavak K.; Allbritton, Nancy L. (15 January 2013). "Micro Total Analysis Systems: Fundamental Advances and Applications in the Laboratory, Clinic, and Field". Analytical Chemistry. 85 (2): 451–472. doi:10.1021/ac3031543. PMC 3546124. PMID 23140554.
  14. Smiddy, Nicole M.; DiSalvo, Matthew; Allbritton-King, Jules D.; Allbritton, Nancy L. (2020). "Microraft array-based platform for sorting of viable microcolonies based on cell-lethal immunoassay of intracellular proteins in microcolony biopsies". The Analyst. 145 (7): 2649–2660. Bibcode:2020Ana...145.2649S. doi:10.1039/D0AN00030B. PMC 7117799. PMID 32048684.
  15. Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Külah, Haluk (3 November 2020). "A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis". Micromachines. 11 (11): 990. doi:10.3390/mi11110990. PMC 7693018. PMID 33153069.
  16. "Nancy Allbritton". UNC Lineberger. Retrieved 8 September 2021.
  17. "Searle Scholars Program : Nancy L. Allbritton (1995)". searlescholars.net. Retrieved 2019-04-19.
  18. "Nancy Allbritton". Arnold and Mabel Beckman Foundation. Archived from the original on 2 August 2018. Retrieved 1 August 2018.
  19. "Academic Senate - Irvine Division - Committee on Scholarly Honors and Awards" (PDF). University of California, Irvine. Retrieved 8 September 2021.
  20. "Nancy Allbritton". UNC Lineberger. Retrieved April 12, 2017.
  21. "NIH Director's Transformative Research Award Recipients 2015 Awardees". National Institutes of Health. 18 September 2018. Retrieved 8 September 2021.
  22. "Chemical Instrumentation". ACS Division of Analytical Chemistry. 12 July 2017. Retrieved 8 September 2021.
  23. "Edward Kidder Graham Faculty Service Award". Office of Faculty Governance at the University of North Carolina at Chapel Hill. Retrieved 8 September 2021.
  24. "Allbritton named 2017 UNC-Chapel Hill Inventor of the Year". UNC College of Arts & Sciences. June 16, 2017. Retrieved 8 September 2021.
  25. Delonas, Cindy (February 27, 2020). "Nancy L. Allbritton Wins Ralph N. Adams Award". LCGC. Retrieved 8 September 2021.
  26. "BME Chair Emeritus Nancy Allbritton to Receive 2021 Pritzker Distinguished Lecture Award". Joint Department of Biomedical Engineering. University of North Carolina, North Carolina State University. May 14, 2021. Retrieved 8 September 2021.
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