Gold nanocage

Gold Nanocages are hollow, porous gold nanoparticles ranging in size from 10 to over 150 nm. They are created by reacting silver nanoparticles with chloroauric acid (HAuCl4) in boiling water.[1] Whereas gold nanoparticles absorb light in the visible spectrum of light (at about 550 nm), gold nanocages absorb light in the near-infrared,[2] where biological tissues absorb the least light. Because they are also biocompatible, gold nanocages are promising as a contrast agent for optical coherence tomography. Gold nanocages also absorb light and heat up (Photothermal effect), killing surrounding cancer cells. Nanocages have been functionalized with cancer-specific antibodies.[3][4]

Gold nanocages synthesis

See also

References
  1. Skrabalak, S. E.; Chen, J.; Sun, Y.; Lu, X.; Au, L.; Cobley, C. M.; Xia, Y. (2008). "Gold nanocages: Synthesis, properties, and applications". Accounts of Chemical Research. 41 (12): 1587–95. doi:10.1021/ar800018v. PMC 2645935. PMID 18570442.
  2. Yavuz, Mustafa S.; Cheng, Yiyun; Chen, Jingyi; Cobley, Claire M.; Zhang, Qiang; Rycenga, Matthew; Xie, Jingwei; Kim, Chulhong; Song, Kwang H.; Schwartz, Andrea G.; Wang, Lihong V.; Xia, Younan (2009). "Gold nanocages covered by smart polymers for controlled release with near-infrared light". Nature Materials. 8 (12): 935–939. Bibcode:2009NatMa...8..935Y. doi:10.1038/nmat2564. PMC 2787748. PMID 19881498.
  3. Jingyi Chen; Fusayo Saeki; Benjamin J. Wiley; Hu Cang; Michael J. Cobb; Zhi-Yuan Li; Leslie Au; Hui Zhang; Michael B. Kimmey; Xingde Li; Younan Xia (2005). "Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents". Nano Lett. 5 (3): 473–7. Bibcode:2005NanoL...5..473C. doi:10.1021/nl047950t. PMID 15755097.
  4. Au, L.; Zheng, D.; Zhou, F.; Li, Z. Y.; Li, X.; Xia, Y. (2008). "A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells". ACS Nano. 2 (8): 1645–52. doi:10.1021/nn800370j. PMC 2718847. PMID 19206368.


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